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A close-up of tissue-engineered construct
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A close-up of tissue-engineered construct

June 1, 2010
A close-up of tissue-engineered construct, a combination of living cells and porous biomaterial that form a living matrix for transplantation in an organism.

Mechanical and biomedical engineer Robert Guldberg and his research team at Georgia Tech is developing 3-D, implantable constructs to enhance the repair and regeneration of bone within an organism. One approach attempts to mimic the natural process of bone repair by implanting cartilage constructs created in an incubator into bone defects.

This project is supported by a grant from the National Science Foundation (NSF). [One of three related images. See Next Image.]

More About this Image: NSF-supported researcher Robert Guldberg and his team at Georgia Tech are developing clinically effective constructs to replace or restore damaged bone and cartilage. Cartilage is bone's natural scaffold during a process called endochondral ossification, which is responsible for bone development, growth and fracture healing.

Also being developed are biomaterials that use genetically modified cells or bioactive scaffolds to stimulate the repair of defects caused by injury or diseases like osteoporosis and osteoarthritis. It is the hope that ultimately this technology will help lead to future advances in next generation orthopedic implants.

Guldberg is also investigating the possibility of mechanically stimulating a bone graft repair by applying controlled, intermittent force using a in vivo hydraulic bone chamber system. Understanding how mechanics influences the repair of tissue-engineered constructs would provide microstructural design objectives for manufacturing effective biomaterial scaffolds. (Year of image: 2000)


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