Quantcast
Last updated on April 17, 2014 at 8:20 EDT
This composite image shows the combined structure of
2974 of 3476

This composite image shows the combined structure of Coxsackievirus A21

June 8, 2010
This composite image shows the combined structure of Coxsackievirus A21 and a "receptor molecule" called ICAM-1, or intracellular adhesion molecule 1. The virus is one of those known to cause the common cold, and the receptor molecule enables the virus to attach to, and infect, host cells. ICAM-1, located on the surface of cells, is represented in blue, and the virus is represented in red. Researchers at Purdue University have determined the structure of the virus-molecule complex by combining images taken using x-ray crystallography and cryo-electron microscopy. Being able to determine the combined structure of the virus and ICAM-1 may teach scientist how the virus recognizes the molecule and how it then anchors to the cell, which represents the initial stages of infection. The virus-molecule complex in the center of this image is a thousandth as wide as a human hair.

This is generally NSF funded research aimed at understanding the structures of viruses. Many people were involved in this research in different capacities, including Marc C. Morais, Kyung H. Choi, Joya S. Koti, Paul R. Chipman, Dwight L. Anderson and Michael G. Rossmann. [One of three related images. See Next Image.] (Date of Image: July 12, 2005)