Molecular Walker's Motion
July 27, 2010
Researchers have synthesized a molecular structure designed from single and double-stranded pieces of DNA that responds to a similarly modeled track, by walking down it autonomously. The walker places foot-over-foot as each appendage is attracted biochemically to the next hairpin along the track. As foot and hairpin make contact, the hairpin unravels. The free end of the hairpin catches a complementary hairpin that is free-floating in the solution in which the whole system is immersed. Both hairpins coil together, forming a "waste duplex" (or the familiarly shaped double helix), and releasing the walker's foot for its next stride. If the walker reaches the end of the track successfully, it leaves behind non-reusable material and the track is spent. Its travels are more perilous than they may seem if it lifts the wrong foot and finds itself trapped between two open hairpins, in which case the walker will fall off, never seeing the end of its track.