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October 21, 2012
In this image, nearby regions on a chain of DNA are indicated using similar colors. The fractal globule has a hierarchical organization; regions nearby along the chain are also nearby in 3-D. Part of this globule is cut out. In the resulting cross-section, the internal spatial clustering is evident. A team of researchers from Harvard University, the Broad Institute of Harvard and the Massachusetts Institute of Technology (MIT), the University of Massachusetts Medical School, and MIT deciphered the 3-D structure of the human genome, paving the way for new insights into genomic function and expanding our understanding of how cellular DNA folds at scales that dwarf the double helix. Credit: Leonid A. Mirny, Maxim Imakaev and Alexnader N. Mirny