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October 21, 2012
This image shows the result of reversing the force constraining a subchain of a fractal globule. The subchain unravels easily because the globule lacks knots, making the subchain accessible. A team of researchers from Harvard University, the Broad Institute of Harvard and the Massachusetts Institute of Technology (MIT), the University of Massachusetts Medical School, and MIT deciphered the 3-D structure of the human genome, paving the way for new insights into genomic function and expanding our understanding of how cellular DNA folds at scales that dwarf the double helix. Credit: Leonid A. Mirny and Maxim Imakaev