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K121A Cholera tcpA mutant
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K121A Cholera tcpA mutant

March 6, 2013
Transmission electron microsope image of Vibrio choleraethat has been negatively stained. Vibrio choleraeis the bacteria responsible for the gastroinestinal disease cholera. In order to get the disease cholera, the bacteria must be able to colonize in the small intestine and a critical factor necessary for this colonization is the toxin-co-regulated pilus(TCP). K121A is a tcpA mutant strain whose pili are clearly visible as 7 nm fibres that form bundles @ 0.2Ð0.3 µm wide, similar to the wild type strain(O395 WT Cholera wild type). However, when viewed at a much lower magnification than this image, the bundles in this mutant strain were much longer than the wild type strain. For more information, see the journal article: T.J. Kirn, M.J. Lafferty, C.M.P Sandoe and R.K. Taylor, 2000, "Delineation of pilin domains required for bacterial association into microcolonies and intestinal colonization", Molecular Microbiology, Vol. 35(4):896-910 JEOL TEM 100CX Credit: Tom Kirn, Ron Taylor, Louisa Howard