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Orex Minerals Announces the Commencement of Production at Santa Cruz

September 2, 2008

VANCOUVER, BRITISH COLUMBIA–(Marketwire – Sept. 2, 2008) – Orex Minerals Inc. (formerly Orex Ventures Inc.) (TSX VENTURE:REX) is pleased to announce that production has commenced on its Santa Cruz Project in Durango State, Mexico a joint venture with Silverex S.A. de C.V.(“Silverex”).

Located in the Sierra Madre Occidental Mountains, Otaez Municipality, midway between Tayoltita (San Dimas) and Topia mining camps, the Santa Cruz Project is in one of the World’s most prolific mineral belts. Santa Cruz is an epithermal gold-silver camp divided into three structural districts, Eastern, Central and Western, as well as the previously operating Santa Cruz Mine.

Our joint venture partner, Silverex reports that the on-site mill at Santa Cruz commenced production of concentrate approximately four weeks ago at the initial rate of 50 tpd and we expect to soon make the first shipment of concentrate to the smelter. Mill feed is coming from the Orozco – La Fragua operations in the Eastern district. The Santa Cruz fire-assay laboratory is also now operational. The intent is to ramp up output production from the mill to its design capacity of 90 tpd.

With regard to Orex’ planned exploration program, Ben Whiting, P. Geo., the Company’s project manager, has engaged two geologists in Mexico and both are currently on-site. Their near term objectives are to commence detailed mapping of the property and sampling over the next two months, and as a result of this work, to identify additional drill targets for a fall start of a drill program.

Ben Whiting, P.Geo., is the Qualified Person and takes responsibility for the technical disclosure in this news release.

Gary Cope, President of Orex, adds, “With the commencement of concentrate production, we have confirmed our belief that Santa Cruz is a great project, providing production revenues as a source of funding, combined with excellent exploration potential.”

About Orex Minerals Inc.

Orex Minerals Inc. is a junior mineral exploration company comprised of highly qualified mining professionals with a focus on the exploration of prospective gold and gold-silver properties in Mexico.

ON BEHALF OF THE BOARD OF DIRECTORS

Gary Cope, President

This News Release may contain forward-looking statements including but not limited to comments regarding the timing and content of upcoming work programs, geological interpretations, receipt of property titles, potential mineral recovery processes, etc. Forward-looking statements address future events and conditions and therefore involve inherent risks and uncertainties. Actual results may differ materially from those currently anticipated in such statements. Orex relies upon litigation protection for forward- looking statements.

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