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Examine the Probiotics Market: Ingredients, Supplements, Foods

October 30, 2008

Reportlinker.com announces that a new market research report related to the Health food industry is available in its catalogue.

The Probiotics Market: Ingredients, Supplements, Foods

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Examines the applications for probiotics in supplements and food products Looks at recent historical trends in U.S. sales of probiotics Details the structure, technologies and relevant government regulatory provisions that govern activities in the industry Considers trends in domestic probiotic sales compared to those in Canada, the European Union and Japan Includes market forecasts through 2013 Profiles the major probiotics companies from the U.S., Canada, the European Union and Japan.

INTRODUCTION

STUDY GOALS AND OBJECTIVES

REASONS FOR DOING THE STUDY

INTENDED AUDIENCE

SCOPE OF REPORT

INFORMATION SOURCES

ANALYST’S CREDENTIALS

RELATED BCC REPORTS

BCC ONLINE SERVICES

DISCLAIMER

SUMMARY

SUMMARY TABLE GLOBAL SALES OF PROBIOTIC INGREDIENTS, SUPPLEMENTS, AND FOODS, THROUGH 2013 ($ MILLIONS)

SUMMARY FIGURE SHARES OF GLOBAL SALES OF PROBIOTICS, BY TYPE, 2006-2013 (%)

OVERVIEW

BACKGROUND

INDUSTRY CONCEPTS

PROBIOTICS AND INTESTINAL HEALTH

RESIDENT AND TRANSIENT PROBIOTICS

PROBIOTIC CLASSIFICATION AND LABELING

PREBIOTICS

SYNBIOTICS

PROBIOTIC DELIVERY SYSTEM

IMPORTANCE OF PROBIOTICS

FORESEEABLE DEVELOPMENTS

Foreseeable Developments (Continued)

THE GLOBAL PROBIOTIC INGREDIENTS INDUSTRY

BACKGROUND

INDUSTRY STRUCTURE

GLOBAL LEADERS

Strategic Alliances, Agreements, and Acquisitions

BioGaia Partners

BioGaia and Ferring Pharmaceuticals

BioGaia and Earth Biochemical Co., Ltd

BioGaia in South Africa

BioGaia in South America

BioGaia in Turkey

BioGaia in the United States

Chr. Hansen Alliances and Acquisition

Chr. Hansen and Valio Ltd.

Chr. Hansen and Urex Biotech

Chr. Hansen and Jarrow Formulas

Chr. Hansen’s Acquires Medipharm

Chr. Hansen and Genome Technology

Danisco Developments

Danisco HOWARU Brand Name

HOWARU–Anyhow you want it

Danisco and New Probiotic Applications

Groupe Danone Alliances

Danone and Yakult

Danone and Integrated Genomics

Institut Rosell-Lallemand’s Strategy

Institut Rosell and Research Collaborators

Institut Rosell Products for Target Markets

Institut Rosell’s Global Marketing Partners

Nebraska Cultures and Wilke Resources

The Probi Network

Probi Research Connections

Probi and Institut Rosell

Probi and Health World

Probi and Metagenics

Probi and NextFoods

Probi and Kraft

Ganeden Biotech–A Significant New Player

The $12 Million Boost from DSM N.V.

Ganeden and PLT

Government Participation

USDA-ARS

U.S. Department of Energy–Joint Genome Institute

Funding Agencies for Probiotic Research in Canada

PROEUHEALTH

PROBIOTIC INGREDIENTS BY TYPE

THE GI TRACT

Immune System Function

Bacterial Genera

PROBIOTICS OF THE LACTOBACILLUS GENUS

L. acidophilus

TABLE 1 PROPRIETARY STRAINS OF L. ACIDOPHILUS, BY PRODUCER

L. acidophilus DDS-1

L. acidophilus LA-1 (L. acidophilus LA-5)

L. acidophilus LAFTI L10

L. acidophilus LB Rosell-52

L. acidophilus NCFM

L. acidophilus SBT-2062, SBT-2071, SBT-2074

L. bulgaricus

L. casei

TABLE 2 PROPRIETARY STRAINS OF L. CASEI, BY PRODUCER

L. casei DN114001 and L. casei immunitas

L. casei LAFTI L26

L. casei 431-CRL-431

L. Casei Shirota

L. helveticus

L. johnsonii

L. plantarum

TABLE 3 PROPRIETARY STRAINS OF L. PLANTARUM, BY PRODUCER

L. reuteri

TABLE 4 PROPRIETARY STRAINS OF L. REUTERI, BY PRODUCER

L. rhamnosus

TABLE 5 PROPRIETARY STRAINS OF L. RHAMNOSUS, BY PRODUCER

L. rhamnosus GG (LGG)

L. rhamnosus GR-1

L. rhamnosus Rosell-11

L. salivarius

PROBIOTICS OF THE BIFIDOBACTERIUM GENUS

B. bifidum (B. lactis)

TABLE 6 PROPRIETARY STRAINS OF B. BIFIDUM, BY PRODUCER

B. lactis BB-12

B. LAFTI B94

B. breve

TABLE 7 PROPRIETARY STRAINS OF B. BREVE, BY PRODUCER

B. infantis

TABLE 8 PROPRIETARY STRAINS OF B. INFANTIS, BY PRODUCER

B. longum

TABLE 9 PROPRIETARY STRAINS OF B. LONGUM, BY PRODUCER

PROBIOTICS OF THE STREPTOCOCCUS GENUS

S. thermophilus

OTHER PROBIOTIC BACTERIA

Bacillus Coagulans (B. coagulans)

B. coagulans GBI-30, 6086 (GanedenBC30)

Lactococcus

Pediococcus

SELECTION CRITERIA AND SPECIES-SPECIFIC BENEFICIAL PHYSIOLOGICAL EFFECTS OF PROBIOTICS

Selection Criteria for Probiotics Strains

TABLE 10 SELECTION CRITERIA FOR PROBIOTICS

Science-based Physiological Benefits

TABLE 11 HEALTH BENEFITS ASSOCIATED WITH LACTOBACILLUS PROBIOTICS

TABLE 11 (CONTINUED)

TABLE 12 HEALTH BENEFITS ASSOCIATED WITH BIFIDOBACTERIUM PROBIOTICS

TABLE 13 HEALTH BENEFITS ASSOCIATED WITH STREPTOCOCCUS PROBIOTICS

MECHANISMS OF PROBIOTIC ACTIVITY

TABLE 14 PROPOSED MECHANISMS OF PROBIOTIC EFFECT

TABLE 14 (CONTINUED)

SALES OF PROBIOTIC INGREDIENTS BY TYPE

INDUSTRY DATA

MARKET DRIVERS

Better Understanding of Probiotics through Sustained Research

Research Targeting Health Conditions and Population Segment

Allergies

Cardiovascular Disease: High Blood Pressure and High Blood Cholesterol

Chronic Constipation

Colorectal Cancer

Inflammatory Bowel Disease: Crohn’s Disease and Ulcerative Colitis

Vaginal Infections

Fine-tuning Consumer Education

The Regulatory Environment

RECENT TRENDS

Global Sales of Probiotic Ingredients by Type

Global Sales of Lactobacillus Probiotic Ingredients

FIGURE 1 GLOBAL SALES OF LACTOBACILLUS PROBIOTICS AS A SHARE OF PROBIOTIC INGREDIENT SALES, 2007 (%)

Global Sales of Bifidobacterium Probiotic Ingredients

FIGURE 2 GLOBAL SALES OF BIFIDOBACTERIUM PROBIOTICS AS A SHARE OF PROBIOTIC INGREDIENT SALES, 2007 (%)

Global Sales of Streptococcus Probiotic Ingredients

FIGURE 3 GLOBAL SALES OF STREPTOCOCCUS PROBIOTICS AS A SHARE OF PROBIOTIC INGREDIENT SALES, 2007 (%)

Total Global Sales of Probiotic Ingredients by Type

TABLE 15 ESTIMATED GLOBAL SALES AND MARKET SHARES OF PROBIOTIC INGREDIENT MANUFACTURERS, 2007

Total Global Sales of Probiotic Ingredients by Region

TABLE 16 ESTIMATED GLOBAL SALES OF PROBIOTIC INGREDIENTS BY REGION, 2007

MAJOR MANUFACTURERS OF PROBIOTIC INGREDIENTS

TABLE 17 MAJOR MANUFACTURERS OF PROBIOTIC INGREDIENTS

SALE PROJECTIONS AND MARKET SIZE

Sale Projections and Market Size (Continued)

TABLE 18 GLOBAL SALES OF PROBIOTIC INGREDIENTS BY TYPE, THROUGH 2013 ($ MILLIONS)

FIGURE 4 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC INGREDIENTS, BY TYPE, 2007 AND 2013 (%)

TABLE 19 GLOBAL SALES OF PROBIOTIC INGREDIENTS BY REGION, THROUGH 2013 ($ MILLIONS)

FIGURE 5 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC INGREDIENTS, BY REGION, 2007 AND 2013 (%)

FIGURE 5 (CONTINUED)

THE GLOBAL PROBIOTIC SUPPLEMENTS INDUSTRY

BACKGROUND

INDUSTRY STRUCTURE

MARKET SHARE BASED ON ACCESS TO PROPRIETARY INGREDIENTS

Full In-house Processing

Bulk Ingredient Suppliers

Contract Manufacturing

Licensing Agreements

MARKET SHARE BASED ON OWNERSHIP OF PROCESSING TECHNOLOGIES

TABLE 20 OWNERSHIP OF PROCESSING TECHNOLOGIES

Bio-tract

LiveBac

Poten-Zyme (also written as potenzyme)

Probiocap

Probio-Tec

STAR Technology

True Delivery Technology

MAKTrek ByPass

Triple-shell Technology

Viablend

MARKET SHARES BASED ON PRODUCT DIFFERENTIATION

Product Differentiation Based on Brand Name

TABLE 21 SAMPLE OF PROBIOTIC SUPPLEMENT BRANDS

Product Differentiation Based on Formulations

Single-species Probiotic Supplement Products

TABLE 22 COMPOSITION OF SINGLE-SPECIES PROBIOTIC SUPPLEMENTS FOR ADULTS

Single-species Supplement from Bio-Energy Systems

Single-species Supplement from Amerifit Nutrition

Single-species Supplement form Ganeden Biotech

Single-species Supplement from Jarrow Formulas

Natren Single-species Supplement

Single-species Supplement from Nebraska Cultures

Single-species Supplement from NOW Foods

Single-species Supplement from Solgar

Multi-species Probiotic Supplement Products

Multi-species Probiotic Supplement Products (continued)

Multi-species Probiotic Supplement Products for Adults

Multi-species Adult Probiotic Supplement from American Biologics

TABLE 23 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM AMERICAN BIOLOGICS

Multi-species Adult Probiotic Supplement from Jarrow Formulas

TABLE 24 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM JARROW FORMULAS

Multi-species Adult Probiotic Supplement from Kirkman

Laboratories

TABLE 25 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM KIRKMAN LABORATORIES

Multispecies Adult Probiotic Supplement from Natren

TABLE 26 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM NATREN

Multi-species Adult Probiotic Supplement from NOW Foods

TABLE 27 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM NOW FOODS

Multispecies Adult Probiotic Supplement from Solaray

TABLE 28 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM SOLARAY

Multispecies Probiotic Supplement Lozenge from Udo’s Choice

TABLE 29 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM UDO’S CHOICE

Multi-species Probiotic Supplement Products for Infants and Children

Multi-species Probiotic Supplement for Infants and Children from American Biologics

TABLE 30 MULTI-SPECIES PROBIOTIC SUPPLEMENTS FOR INFANTS AND CHILDREN FROM AMERICAN BIOLOGICS

Multispecies Probiotic Supplement for Infants and Children from Country Life

TABLE 31 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR INFANTS AND CHILDREN FROM COUNTRY LIFE

Multispecies Probiotic Supplement for Infants and Children from Jarrow Formulas

TABLE 32 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR INFANTS AND CHILDREN FROM JARROW FORMULAS

Multispecies Probiotic Supplement for Infants and Children from Nature’s Plus

TABLE 33 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR INFANTS AND CHILDREN FROM NATURE’S PLUS

Multi-species Probiotic Supplement for Infants and Children from Udo’s

Choice

TABLE 34 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR CHILDREN FROM UDO’S CHOICE

Product Differentiation Based on Probiotic Dosage

PROBIOTIC SUPPLEMENTS FOR ANIMAL USE

Market Potential for Animal Probiotic Supplements

Market Potential for Animal Probiotic Supplements (Continued)

TABLE 35 U.S. PET OWNERSHIP, BY TYPE, 2007

Samples of Probiotic Supplements for Animals

TABLE 36 PROBIOTIC SUPPLEMENTS FOR ANIMAL USE

Multi-species Probiotic Supplement for Pets from Jarrow Formulas

TABLE 37 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR PETS FROM JARROW FORMULAS

Multi-species Probiotic Supplement from Natur’s Way

TABLE 38 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR PETS FROM NATURE’S WAY

DISTRIBUTION CHANNELS FOR PROBIOTIC SUPPLEMENTS

The Internet as a Distribution Channel

SALES OF PROBIOTIC SUPPLEMENTS BY TYPE OF FORMULATION

INDUSTRY DATA

MARKET DRIVERS

Science-based Substantiation of Beneficial Claims

Continuing Consumer Education

Demographics

Continuing Improvement in Processing Technologies

Expanding the Market Base–Animal Supplements

Product Innovations

Carving a Niche

New Product Format

BioGaia’s Drops, Lozenges, and Straws

Ganeden’s Topical applications

New application frontier–Cosmetics

Natren’s Probiotic Cosmetics

Regulatory Changes and Industry Reform

RECENT SALES TRENDS

Global Sales of Probiotic Supplements by Type

Global Sales of Probiotic Supplements in Capsule Form

FIGURE 6 GLOBAL SALES OF PROBIOTIC CAPSULES AS A SHARE OF PROBIOTIC SUPPLEMENT SALES, 2007 (%)

Global Sales of Probiotic Supplements in Tablet Form

FIGURE 7 GLOBAL SALES OF PROBIOTIC TABLETS AS A SHARE OF PROBIOTIC SUPPLEMENT SALES, 2007 (%)

Global Sales of Probiotic Supplements in Powder Form

FIGURE 8 GLOBAL SALES OF PROBIOTIC POWDER AS A SHARE OF PROBIOTIC SUPPLEMENT SALES, 2007 (%)

Total Global Sales of Probiotic Supplements by Type

TABLE 39 ESTIMATED GLOBAL SALES AND MARKET SHARES OF PROBIOTIC SUPPLEMENT MANUFACTURERS, 2007

MAJOR PROBIOTIC SUPPLEMENT MANUFACTURERS

TABLE 40 MAJOR MANUFACTURERS OF PROBIOTIC SUPPLEMENTS

TABLE 40 (CONTINUED)

SALE PROJECTIONS AND MARKET SIZE

Sale Projections and Market Size (Continued)

TABLE 41 GLOBAL SALES OF PROBIOTIC SUPPLEMENTS BY TYPE, THROUGH 2013 ($ MILLIONS)

FIGURE 9 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC SUPPLEMENTS, BY TYPE, 2007 AND 2013 (%)

FIGURE 9 (CONTINUED)

TABLE 42 GLOBAL SALES OF PROBIOTIC SUPPLEMENTS BY REGION, THROUGH 2013 ($ MILLIONS)

FIGURE 10 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC SUPPLEMENTS, BY REGION, 2007 AND 2013 (%)

THE GLOBAL PROBIOTIC FOODS INDUSTRY

BACKGROUND

INDUSTRY STRUCTURE

INDUSTRY DYNAMICS

Structural Changes in Dairy Farming

Structural Changes in Dairy Processing

Stonyfield Farm Connections

Stonyfield Farm and Brown Cow

The Danone Groupe Partnership

Strategic Ingredient Sourcing from BioGaia

International Sister Companies

Lifeway Foods Extends its Reach

The Acquisition of Helios Nutrition

Entry into Foodservice Market

New Sales Concept

Growing the Niche

Private Labels and Contract Manufacturing

PROBIOTIC FOODS BY TYPE

STARTER CULTURE

TABLE 43 BRANDED COMMERCIAL STARTER CULTURES, BY PRODUCER AND APPLICATION

DAIRY-BASED PROBIOTIC FOOD PRODUCTS BY TYPE

Yogurt

Natural-set Yogurt

Stirred Yogurt

Drinkable Yogurt

The Probiotic Content of Yogurt

The Probiotic Content … (Continued)

TABLE 44 PROBIOTIC COMPOSITION OF SELECT YOGURT BRANDS

Kefir

Kefir (Continued)

TABLE 45 PROBIOTIC COMPOSITION OF SELECT KEFIR BRANDS

Dairy-based Cultured Probiotic Drinks

TABLE 46 PROBIOTIC COMPOSITION OF SELECT CULTURED PROBIOTIC DRINKS

Non-dairy Based Cultured Drinks

TABLE 47 PROBIOTIC COMPOSITION OF SOY-BASED PROBIOTIC YOGURT

RECENT AND EMERGING COMMERCIALLY SIGNIFICANT PROBIOTIC FOODS

Probiotic Cheese Products

Butler’s Probiotic Delicious Creamy Handmade Cheese

TABLE 48 PROBIOTIC CHEESE, BY MANUFACTURER

Probiotic Infant Formula in the U.S. Market

Probiotic Ice Cream and Iced Lollies

Probiotic Breakfast and Snack Foods

TABLE 49 SAMPLE OF PROBIOTIC BREAKFAST AND SNACK BARS

Probiotic Drinks and Juices

TABLE 50 SAMPLE OF PROBIOTIC DRINKS AND JUICES

SALES OF PROBIOTIC FOODS BY TYPE

INDUSTRY DATA

MARKET DRIVERS

Untapped Market Potential

Consumer Preferences

Emerging Probiotic Foods

Food Processing Challenge

RECENT TRENDS IN PROBIOTIC FOOD SALES

Global Sales of Probiotic Foods by Type

Global Sales of Probiotic Yogurt

FIGURE 11 GLOBAL SALES OF PROBIOTIC YOGURT AS A SHARE OF PROBIOTIC FOODS, 2007 (%)

Global Sales of Probiotic Kefir

FIGURE 12 GLOBAL SALES OF PROBIOTIC KEFIR, AS A SHARE OF PROBIOTIC FOODS, 2007 (%)

Global Sales of Probiotic Cultured Drinks

FIGURE 13 GLOBAL SALES OF PROBIOTIC CULTURED DRINKS AS A SHARE OF PROBIOTIC FOODS, 2007 (%)

Global Sales of Probiotic Cheese Products

FIGURE 14 GLOBAL SALES OF PROBIOTIC CHEESE PRODUCTS AS A SHARE OF PROBIOTIC FOODS, 2007 (%)

Total Global Sales of Probiotic Foods by Type

TABLE 51 ESTIMATED GLOBAL SALES AND MARKET SHARES OF PROBIOTIC FOOD MANUFACTURERS, 2007

Total Global Sales of Probiotic Foods by Region

TABLE 52 ESTIMATED GLOBAL SALES OF PROBIOTIC FOODS BY REGION, 2007

MAJOR MANUFACTURERS OF PROBIOTIC FOODS

TABLE 53 MAJOR PROBIOTIC FOOD MANUFACTURERS

SALE PROJECTIONS AND MARKET SIZE

TABLE 54 GLOBAL SALES OF PROBIOTIC FOODS, BY TYPE, THROUGH 2013 ($ MILLIONS)

FIGURE 15 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC FOODS, BY TYPE, 2007 AND 2013 (%)

TABLE 55 GLOBAL SALES OF PROBIOTIC FOODS, BY REGION, THROUGH 2013 ($ MILLIONS)

FIGURE 16 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC FOODS, BY REGION, 2007 AND 2013 (%)

REGULATORY GUIDELINES FOR THE PROBIOTICS INDUSTRY

BACKGROUND

THE CODEX ALIMENTARIUS

A BRIEF HISTORY OF THE CODEX: THE JOINT FAO-WHO FOOD PROGRAM

CODEX GUIDELINES FOR THE EVALUATION OF PROBIOTICS

Genus-Species-Strain

Screening of Potential Probiotics

Probiotic Safety Considerations

Probiotic Health Claims

Probiotic Product Labeling

Codex Guidelines on Nutrition Claims

Codex Standard for Food Additives

CODEX STANDARD FOR GOOD MANUFACTURING PRACTICE (GMP)

CODEX STANDARD FOR FERMENTED MILK PRODUCTS

TABLE 56 CODEX STANDARDS FOR FERMENTED MILK PRODUCTS

U.S. REGULATORY PROVISIONS

REGULATIONS RELATING TO INGREDIENTS

Legal Definition of Ingredient Products

Definition of a Food Additive

GRAS Provisions

The Food Additive Petition Process

Premarket Review Provision for New Dietary Ingredient

REGULATIONS RELATING TO DIETARY SUPPLEMENTS

Legal Definition of a Supplement Product

Approved Product Claims for Dietary Supplements

Supplement Product Health Claims

The Nutrition Labeling and Education Act (NLEA) of 1990

The Food and Drug Administration Modernization Act (FDAMA) of 1997

Qualified Health Claims

Product Nutrient Content Claims

Structural-Function Claims for Supplement Products

Recent and Foreseeable Developments in the U.S. Regulatory Process

Scientific Evaluation of Health Claims

Changes in Manufacturing Practices

Guidance Relating to Complementary and Alternative Medicine Products

REGULATORY PROVISIONS RELATING TO FOOD PRODUCTS

Legal Requirements for Yogurt Products

TABLE 57 YOGURT CLASSIFICATION

GRAS Status of Probiotic Food Ingredients

Approved Food Product Claims

Probiotic Food Labeling Gaps

General Health Claims

Probiotic Content Information

Nutrient Content Claims

CANADIAN REGULATORY PROVISIONS

HEALTH CANADA OVERSIGHT

Canada’s Natural Health Products Regulations

Definition of a Natural Health Product

Regulations Relating to Product Manufacturing

Licensing Requirement

Good Manufacturing Practices (GMPs)

Additional Requirements for Probiotics

Characterization of Probiotics

Probiotic Efficacy Considerations

Probiotic Safety Considerations and Banned Probiotic Strains

Compliance Policy

EU REGULATORY PROVISIONS

A SNAPSHOT OF THE EU

PRODUCT HEALTH CLAIMS

Coverage of the Regulation

General Conditions for Claims

Scientific Substantiation of Claims

Restrictions on the Use of Certain Health Claims

Compliance Deadline

Transitional and Safeguard Provisions

REGULATORY PROVISIONS IN JAPAN

MINISTRY OF HEALTH, LABOR, AND WELFARE OVERSIGHT

FOOD WITH HEALTH CLAIMS

Food with Nutrient Function Claims (FNFC)

Food for Specified Health Uses (FOSHU)

TABLE 58 HEALTH CLAIMS UNDER FOSHU

Requirements for FOSHU Approval

FOODS FOR SPECIAL DIETARY USES (FOSDU)

Requirements for FOSDU Labeling

PROHIBITION OF EXAGGERATED AND MISLEADING CLAIMS

THE ROLE OF EXPERT GROUPS AND PROFESSIONAL ASSOCIATIONS

The International Scientific Association for Probiotics and Prebiotics (ISAPP)

The ISAPP Industry Advisory Committee

Recommended Industry Standards

The European Food & Feed Cultures Association (EFFCA)

The International Probiotics Association (IPA)

The IPA Seal of Quality

The U.S. Institute of Medicine (IOM)

The U.S. National Yogurt Association (NYA)

NYA Seal

NYA Probiotic Council

The American Dietetic Association (ADA)

The U.S. Council for Responsible Nutrition (CRN)

Role of Consumer Watchdog Groups

The Council for Agricultural Science and Technology (CAST)

ConsumerLab.com

TECHNOLOGY AND PATENT ANALYSIS

BACKGROUND

CURRENT PROCESSING TECHNOLOGIES

FERMENTATION

Lactic Acid Fermentation

Batch Fermentation

Limitations of the Fermentation Process

CENTRIFUGATION

Differential Centrifugation

ULTRAFILTRATION

Nanofiltration

LYOPHILIZATION (FREEZE-DRYING)

Lyophilizer

ENCAPSULATION AND TABLETING

Spray-drying Encapsulation Technologies

Tableting

Emerging Encapsulation Technologies

Cell Biotech and Dual-coating

EnCoate and Bioshield

Riddet Centre and Biopolymers

New Coating Materials

PATENT ANALYSIS

PATENTS RELATING TO EXISTING AND NEW PROBIOTIC STRAINS

TABLE 59 U.S. PATENT AWARDS FOR PROBIOTIC SPECIES, BY TYPE, 2006-2007

TABLE 60 U.S. PATENT AWARDS FOR PROBIOTIC SPECIES BY REGION, 2006-2007

Sample of Patents for Existing Probiotics

Lactic Acid Bacteria for the Treatment and or Prophylaxis of Giardiasis

Lactobacillus Reuteri Useful as Probiotics

Enzyme Isolated from a Bifidobacterium

Sample of Patents for New Probiotic Strains

Lactic Acid Producing Bacteria for use as a Probiotic in the Human Vagina

Strain of Microorganism Lactobacillus Fermentum ME-3 as Novel Anti-microbial and Antioxidative Probiotic

Microorganism Pediococcus Pentosaceus EROM101, Having Immune Enhancement, Anti-cancer, and Antimicrobial Activities

Strain of Lactic Acid Bacterium and Edible Compositions, Drugs and Veterinary Products Containing It

NCC2705–The Genome of a Bifidobacterium

Lactobacilli Expressing Biologically Active Polypeptides and Uses Thereof

Composition Comprising a Lactobacillus Pentosus Strain and Uses Thereof

PATENTS RELATING TO PROBIOTIC APPLICATIONS

TABLE 61 U.S. PATENT AWARDS FOR PROBIOTIC APPLICATIONS BY TYPE, 2006-2007

Sample of Patents for Probiotic Starter Culture

Compositions and methods for producing fermentation products and residuals

Lactobacillus stains and use thereof in fermentation for L-lactic acid production

Fragment of L. Lactis Plasmid Conferring Antiphage Activity and Uses Thereof

Sample of Patents for Probiotic Fermented Products

Ferment Activator Based on Lactic Acid Bacteria and Method for Preparing a Dairy Product Using Same

Method for Producing Fermented Milk Product

Powder for Preparation of a Probiotic Yogurt Food

Sample of Patents for Probiotic Therapeutic Products

Method for Preventing or Treating the Development of Respiratory Allergies

Kit with Enteral Dietary Composition Consisting of Streptococcus Thermophilus, Bifidobacterium

Infantis, and Bifidobacterium Longum

Bifidobacterium in the Treatment of Inflammatory Disease

Selection and Uses of Lactic Bacteria Strains Modulating Non-specific Immunity

Lactic Acid Bacteria-containing Probiotics Products

Selection and Use of Lactic Acid Bacteria for Reducing Inflammation Caused By Helicobacter

Lactobacillus paracasei subsp. Paracasei strain antibacterial against H. Pylori and E. coli

Microorganism Strain of GM-020 of Lactobacillus Rhamnosus and its Use for Treating Obesity

PATENTS RELATING TO PROBIOTIC PROCESSING TECHNOLOGIES

TABLE 62 U.S. PATENTS FOR SELECT PROCESSING TECHNOLOGIES BY TYPE, 2006-2007

Lyophilization of Human Platelets

Formulations to Increase In Vivo Survival of Probiotic Bacteria and Extend Their Shelf life

Prebiotic and Preservative Uses of Oil-emulsified Probiotic Encapsulations

Encapsulation of Sensitive Liquid Components Into a Matrix to Obtain Discrete Shelf-stable Particles

Tablets Containing Heat Sensitive Materials and Method for Forming Thereof

Tablets Comprising Microorganisms and Method for Preparation of the Tablets

COMPANY PROFILES

BACKGROUND

GLOBAL MANUFACTURERS OF PROBIOTIC INGREDIENTS

BIO-ENERGY SYSTEMS, INC.

BIOGAIA

CHR. HANSEN A-S

CHR. HANSEN, INC.

DANISCO CULTURES A-S

GROUPE DANONE

THE DANNON CO., INC

ROYAL DSM N.V. (DSM FOOD SPECIALTIES)

INSTITUT ROSELL-LALLEMAND

MORINAGA MILK INDUSTRY

NEBRASKA CULTURES

NESTLE USA, INC

PROBI AB

SNOW BRAND MILK PRODUCTS

UREX BIOTECH, INC

YAKULT HONSHA COMPANY, LTD

MAJOR MANUFACTURERS OF PROBIOTIC SUPPLEMENTS

AMERICAN BIOLOGICS

AMERIFIT NUTRITION INC.

BIO-K+ INTERNATIONAL INC

COUNTRY LIFE VITAMINS

ENZYMATIC THERAPY

GANEDEN BIOTECH

GARDEN OF LIFE, INC

JARROW FORMULAS

KIRKMAN LABORATORIES

NATREN

NATROL, INC.

NATURE’S PLUS-NATURAL ORGANICS, INC.

NATURE’S WAY

NOW FOODS

NUTRACEUTICAL CORP

NUTRACEUTIX, INC

SOLGAR VITAMIN & HERB CO

UAS LABORATORIES

MAJOR PROBIOTIC FOOD MANUFACTURERS

ARLA FOODS

CASCADE FRESH

CAMPINA

DAIRY FARMERS OF AMERICA, INC

DAIRY CREST GROUP, PLC

FONTERRA COOPERATIVE GROUP

FROMAGERIES BEL

GENERAL MILLS

HP HOOD, LLC

JOHANNA FOODS, INC.

KRAFT FOODS

LIFEWAY FOODS

MEIJI DAIRIES CORPORATION

OLD HOME FOODS, INC.

PARMALAT S.P.A

SPRINGFIELD CREAMERY, INC.

STONYFIELD FARM

TILLAMOOK COUNTY CREAMERY ASSOCIATION

UNILEVER

VALIO GROUP

WALLABY YOGURT CO

WELLS’ DAIRY, INC.

WIMM-BILL-DANN FOODS

LIST OF TABLES

SUMMARY TABLE GLOBAL SALES OF PROBIOTIC INGREDIENTS, SUPPLEMENTS, AND FOODS, THROUGH 2013 ($ MILLIONS)

TABLE 1 PROPRIETARY STRAINS OF L. ACIDOPHILUS, BY PRODUCER

TABLE 2 PROPRIETARY STRAINS OF L. CASEI, BY PRODUCER

TABLE 3 PROPRIETARY STRAINS OF L. PLANTARUM, BY PRODUCER

TABLE 4 PROPRIETARY STRAINS OF L. REUTERI, BY PRODUCER

TABLE 5 PROPRIETARY STRAINS OF L. RHAMNOSUS, BY PRODUCER

TABLE 6 PROPRIETARY STRAINS OF B. BIFIDUM, BY PRODUCER

TABLE 7 PROPRIETARY STRAINS OF B. BREVE, BY PRODUCER

TABLE 8 PROPRIETARY STRAINS OF B. INFANTIS, BY PRODUCER

TABLE 9 PROPRIETARY STRAINS OF B. LONGUM, BY PRODUCER

TABLE 10 SELECTION CRITERIA FOR PROBIOTICS

TABLE 11 HEALTH BENEFITS ASSOCIATED WITH LACTOBACILLUS PROBIOTICS

TABLE 12 HEALTH BENEFITS ASSOCIATED WITH BIFIDOBACTERIUM PROBIOTICS

TABLE 13 HEALTH BENEFITS ASSOCIATED WITH STREPTOCOCCUS PROBIOTICS

TABLE 14 PROPOSED MECHANISMS OF PROBIOTIC EFFECT

TABLE 15 ESTIMATED GLOBAL SALES AND MARKET SHARES OF PROBIOTIC INGREDIENT MANUFACTURERS, 2007

TABLE 16 ESTIMATED GLOBAL SALES OF PROBIOTIC INGREDIENTS BY REGION, 2007

TABLE 17 MAJOR MANUFACTURERS OF PROBIOTIC INGREDIENTS

TABLE 18 GLOBAL SALES OF PROBIOTIC INGREDIENTS BY TYPE, THROUGH 2013 ($ MILLIONS)

TABLE 19 GLOBAL SALES OF PROBIOTIC INGREDIENTS BY REGION, THROUGH 2013 ($ MILLIONS)

TABLE 20 OWNERSHIP OF PROCESSING TECHNOLOGIES

TABLE 21 SAMPLE OF PROBIOTIC SUPPLEMENT BRANDS

TABLE 22 COMPOSITION OF SINGLE-SPECIES PROBIOTIC SUPPLEMENTS FOR ADULTS

TABLE 23 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM AMERICAN BIOLOGICS

TABLE 24 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM JARROW FORMULAS

TABLE 25 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM KIRKMAN LABORATORIES

TABLE 26 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM NATREN

TABLE 27 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM NOW FOODS

TABLE 28 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM SOLARAY

TABLE 29 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR ADULTS FROM UDO’S CHOICE

TABLE 30 MULTI-SPECIES PROBIOTIC SUPPLEMENTS FOR INFANTS AND CHILDREN FROM AMERICAN BIOLOGICS

TABLE 31 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR INFANTS AND CHILDREN FROM COUNTRY LIFE

TABLE 32 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR INFANTS AND CHILDREN FROM JARROW FORMULAS

TABLE 33 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR INFANTS AND CHILDREN FROM NATURE’S PLUS

TABLE 34 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR CHILDREN FROM UDO’S CHOICE

TABLE 35 U.S. PET OWNERSHIP, BY TYPE, 2007

TABLE 36 PROBIOTIC SUPPLEMENTS FOR ANIMAL USE

TABLE 37 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR PETS FROM JARROW FORMULAS

TABLE 38 MULTI-SPECIES PROBIOTIC SUPPLEMENT FOR PETS FROM NATURE’S WAY

TABLE 39 ESTIMATED GLOBAL SALES AND MARKET SHARES OF PROBIOTIC SUPPLEMENT MANUFACTURERS, 2007

TABLE 40 MAJOR MANUFACTURERS OF PROBIOTIC SUPPLEMENTS

TABLE 41 GLOBAL SALES OF PROBIOTIC SUPPLEMENTS BY TYPE, THROUGH 2013 ($ MILLIONS)

TABLE 42 GLOBAL SALES OF PROBIOTIC SUPPLEMENTS BY REGION, THROUGH 2013 ($ MILLIONS)

TABLE 43 BRANDED COMMERCIAL STARTER CULTURES, BY PRODUCER AND APPLICATION

TABLE 44 PROBIOTIC COMPOSITION OF SELECT YOGURT BRANDS

TABLE 45 PROBIOTIC COMPOSITION OF SELECT KEFIR BRANDS

TABLE 46 PROBIOTIC COMPOSITION OF SELECT CULTURED PROBIOTIC DRINKS

TABLE 47 PROBIOTIC COMPOSITION OF SOY-BASED PROBIOTIC YOGURT

TABLE 48 PROBIOTIC CHEESE, BY MANUFACTURER

TABLE 49 SAMPLE OF PROBIOTIC BREAKFAST AND SNACK BARS

TABLE 50 SAMPLE OF PROBIOTIC DRINKS AND JUICES

TABLE 51 ESTIMATED GLOBAL SALES AND MARKET SHARES OF PROBIOTIC FOOD MANUFACTURERS, 2007

TABLE 52 ESTIMATED GLOBAL SALES OF PROBIOTIC FOODS BY REGION, 2007

TABLE 53 MAJOR PROBIOTIC FOOD MANUFACTURERS

TABLE 54 GLOBAL SALES OF PROBIOTIC FOODS, BY TYPE, THROUGH 2013 ($ MILLIONS)

TABLE 55 GLOBAL SALES OF PROBIOTIC FOODS, BY REGION, THROUGH 2013 ($ MILLIONS)

TABLE 56 CODEX STANDARDS FOR FERMENTED MILK PRODUCTS

TABLE 57 YOGURT CLASSIFICATION

TABLE 58 HEALTH CLAIMS UNDER FOSHU

TABLE 59 U.S. PATENT AWARDS FOR PROBIOTIC SPECIES, BY TYPE, 2006-2007

TABLE 60 U.S. PATENT AWARDS FOR PROBIOTIC SPECIES BY REGION, 2006-2007

TABLE 61 U.S. PATENT AWARDS FOR PROBIOTIC APPLICATIONS BY TYPE, 2006-2007

TABLE 62 U.S. PATENTS FOR SELECT PROCESSING TECHNOLOGIES BY TYPE, 2006-2007

LIST OF FIGURES

SUMMARY FIGURE SHARES OF GLOBAL SALES OF PROBIOTICS, BY TYPE, 2006-2013 (%)

FIGURE 1 GLOBAL SALES OF LACTOBACILLUS PROBIOTICS AS A SHARE OF PROBIOTIC INGREDIENT SALES, 2007 (%)

FIGURE 2 GLOBAL SALES OF BIFIDOBACTERIUM PROBIOTICS AS A SHARE OF PROBIOTIC INGREDIENT SALES, 2007 (%)

FIGURE 3 GLOBAL SALES OF STREPTOCOCCUS PROBIOTICS AS A SHARE OF PROBIOTIC INGREDIENT SALES, 2007 (%)

FIGURE 4 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC INGREDIENTS, BY TYPE, 2007 AND 2013 (%)

FIGURE 5 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC INGREDIENTS, BY REGION, 2007 AND 2013 (%)

FIGURE 6 GLOBAL SALES OF PROBIOTIC CAPSULES AS A SHARE OF PROBIOTIC SUPPLEMENT SALES, 2007 (%)

FIGURE 7 GLOBAL SALES OF PROBIOTIC TABLETS AS A SHARE OF PROBIOTIC SUPPLEMENT SALES, 2007 (%)

FIGURE 8 GLOBAL SALES OF PROBIOTIC POWDER AS A SHARE OF PROBIOTIC SUPPLEMENT SALES, 2007 (%)

FIGURE 9 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC SUPPLEMENTS, BY TYPE, 2007 AND 2013 (%)

FIGURE 10 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC SUPPLEMENTS, BY REGION, 2007 AND 2013 (%)

FIGURE 11 GLOBAL SALES OF PROBIOTIC YOGURT AS A SHARE OF PROBIOTIC FOODS, 2007 (%)

FIGURE 12 GLOBAL SALES OF PROBIOTIC KEFIR, AS A SHARE OF PROBIOTIC FOODS, 2007 (%)

FIGURE 13 GLOBAL SALES OF PROBIOTIC CULTURED DRINKS AS A SHARE OF PROBIOTIC FOODS, 2007 (%)

FIGURE 14 GLOBAL SALES OF PROBIOTIC CHEESE PRODUCTS AS A SHARE OF PROBIOTIC FOODS, 2007 (%)

FIGURE 15 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC FOODS, BY TYPE, 2007 AND 2013 (%)

FIGURE 16 ESTIMATED SHARES OF GLOBAL SALES OF PROBIOTIC FOODS, BY REGION, 2007 AND 2013 (%)

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The Probiotics Market: Ingredients, Supplements, Foods

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