Business News Archive - September 22, 2005
The relationship between tissue rigidity and tumor formation is fairly well established; however, what is not so well understood is what happens on a molecular level that contributes to such stiffness. Now, for the first time, researchers at the University of Pennsylvania School of Medicine have shown that tumor formation is generated by a complex interaction of both mechanical as well as chemical signals, and the resulting tissue stiffening induces molecular signals that promote the cancerous behavior of cells. Penn's interdisciplinary research team-drawn from the fields of Biomedical Engineering and Cell and Developmental Biology-has demonstrated clearly that force, growth, and tumor behavior are inextricably linked and this enhanced understanding of the necessary fusion of these factors may lead to the development of new tumor therapies or targets.
- Any of various tropical Old World birds of the family Indicatoridae, some species of which lead people or animals to the nests of wild honeybees. The birds eat the wax and larvae that remain after the nest has been destroyed for its honey.