In the Highly Competitive MRSA cSSSI Market, Cubist’s Sivextro Will be Positively Differentiated from Current and Emerging Therapies

April 3, 2014

Lipoglycopeptides Dalvance and Oritavancin Will Find Favorable Uptake as Convenient Outpatient Anti-MRSA Agents, According to Findings from Decision Resources Group

BURLINGTON, Mass., April 3, 2014 /PRNewswire/ — Decision Resources Group finds that following its launch, Cubist’s second generation oxazolidinone Sivextro will be highly differentiated from other anti-MRSA (methicillin-resistant Staphylococcus aureus) agents for the treatment of complicated skin and skin structure infections (cSSSIs) due to MRSA. In particular, Sivextro’s once-daily dosing, shorter course of therapy, and its potential for lower treatment-related adverse events are notable improvements over Pfizer’s Zyvox/Zyvoxid, the current market share leader for MRSA cSSSIs. Accordingly, in March 2014, the FDA’s Anti-Infective Drugs Advisory Committee unanimously recommended Sivextro’s approval for the treatment of cSSSIs.


Other key findings from the DecisionBase report entitled Methicillin-Resistant Staphylococcus Aureus Complicated Skin and Skin Structure Infections: In The Crowded MRSA cSSSI Market, How Will Emerging Therapies Differentiate Themselves from Current Standard of Care?:

    --  Importance of early clinical response rates for MRSA cSSSIs: Less than
        40 percent of surveyed European infectious disease (ID) specialists
        chose early clinical response rate among their top three most persuasive
        end points when evaluating new antibiotics for MRSA cSSSIs, compared
        with nearly 60 percent of surveyed U.S. ID specialists who ranked this
        end point accordingly. This finding highlights the impact of the FDA's
        recommendation for use of early response as the primary end point in
        clinical trials.
    --  Payer receptivity to new anti-MRSA agents with a shorter length of
        therapy: As U.S. hospitals aim to contain healthcare costs, hospital
        pharmacy directors will seek therapies that help reduce the cost of
        managing MRSA cSSSIs, including agents that promote earlier discharge.
        Nearly two-thirds of surveyed pharmacy directors support formulary
        inclusion of agents with a shorter course of therapy than Zyvox/Zyvoxid,
        and are priced similarly or at a premium to a seven-day course of
    --  Future impact of Dalvance and oritavancin on current therapies: Surveyed
        ID specialists indicate that Durata's Dalvance and The Medicines
        Company's oritavancin will gain uptake at the expense of vancomycin and
        Cubist's Cubicin. With long systemic half-lives allowing for convenient
        once-weekly or single dosing, respectively, we expect both agents will
        compete for MRSA cSSSI patients who require further antibiotic therapy
        at discharge or are candidates for outpatient parenteral antibiotic

Comments from Decision Resources Group Analyst Maria Ascano Ph.D.:

    --  "Although ID specialists consider efficacy to be the most important drug
        attribute for treating MRSA cSSSIs, the availability of many highly
        effective therapies will make it difficult for new entrants to
        differentiate themselves on efficacy improvements alone. However,
        because this segment of the market is dominated by older less
        well-tolerated parenteral antibiotics, developers can highlight safety
        and delivery improvements to capitalize on market opportunities."
    --  "Therapies that can help promote early discharge or reduce hospital
        admissions will gain favorable uptake as healthcare providers aim to
        reduce hospital-associated costs. Therefore, agents providing convenient
        use in the outpatient setting, including availability in IV and oral
        formulations, shorter courses of therapy, or infrequent dosing, will be
        highly differentiated in this crowded market segment."

About Decision Resources Group

Decision Resources Group offers best-in-class, high-value information and insights on critical issues within the healthcare industry. Clients rely on this analysis and data to make informed decisions. Find out more at www.DecisionResourcesGroup.com.

All company, brand, or product names contained in this document may be trademarks or registered trademarks of their respective holders.

For more information, contact:

Decision Resources Group

Christopher Comfort



Logo – http://photos.prnewswire.com/prnh/20130103/MM36768LOGO

SOURCE Decision Resources Group

Source: PR Newswire

comments powered by Disqus