Quantcast

For Moderate to Severe Systemic Lupus Erythematosus, Epratuzumab Has the Potential to Offer Improvements over IV Belimumab in Health-Related Quality of Life and Time to Response

April 28, 2014

Rheumatologists Cite Improved Health-Related Quality of Life, Improved Effect in Disease Activity among Unmet Needs, According to Findings from Decision Resources Group

BURLINGTON, Mass., April 28, 2014 /PRNewswire/ — Decision Resources Group finds that surveyed U.S. and EU5 rheumatologists agree that new therapies for the treatment of moderate to severe systemic lupus erythematosus (SLE) that offer improved effect on disease activity and renal organ domain scores over current therapies would be well received and poised for strong uptake. This finding reflects thought leader opinion that IV belimumab (GlaxoSmithKline’s Benlysta) offers only modest efficacy on these attributes, while therapies typically used to treat moderate to severe renal manifestations are associated with a risk of serious side effects that limit their widespread use in patients with early stage renal involvement. Based on currently available clinical data and thought leader opinion, UCB’s emerging therapy epratuzumab has the potential to offer improvements over belimumab in health-related quality of life and time to response, as well as an acceptable safety profile.

http://photos.prnewswire.com/prnvar/20130103/MM36768LOGO

Other key findings from the DecisionBase 2014 report entitled Systemic Lupus Erythematosus: Significant Market Opportunity Awaits Therapies Offering Improvements in Efficacy over IV Belimumab for the Moderate to Severe Patient Segment:

    --  Lupuzor, epratuzumab, blisibimod: According to clinical data, emerging
        therapies rigerimod (ImmuPharma's Lupuzor, P140), epratuzumab and
        Anthera Pharmaceuticals' blisibimod may offer improved efficacy in
        disease activity over belimumab, with the latter agent specifically
        targeting the severe SLE patient segment; however, thought leaders are
        waiting for additional data to differentiate these agents from
        belimumab.
    --  Unmet need: In addition to improvements in efficacy, surveyed
        rheumatologists identify notable unmet need for therapies associated
        with a lower risk of serious infections. While thought leaders perceive
        that belimumab carries a relatively low risk, mycophenolate mofetil
        (Roche/Galenica's CellCept, generics) and rituximab (Biogen
        Idec/Roche/Genentech/Chugai/Zenyaku Kogyo's Rituxan, Roche's MabThera)
        are associated with higher risk of serious infections. To date,
        epratuzumab carries a similar risk as belimumab based on pooled safety
        data from completed and ongoing trials.
    --  Formulary inclusion: Surveyed U.S. managed care organization (MCO)
        pharmacy directors are receptive to new therapies that offer improved
        patient response rate on a composite index, with 85 percent willing to
        reimburse therapies offering improvement over belimumab even if priced
        at a greater than 5 percent premium to belimumab.

Comments from Decision Resources Group Analyst Alexandra Makarova, M.D., Ph.D.:

    --  "In light of the modest efficacy offered by the approved agent IV
        belimumab, and the safety concerns surrounding use of rituximab and
        mycophenolate mofetil, interviewed thought leaders indicate a need for
        drugs with greater efficacy that are also accompanied by a suitable
        safety profile. To date, emerging agent epratuzumab has the potential to
        fulfill these unmet needs."
    --  "The responses from our survey of MCO pharmacy directors indicate that
        improved patient response rates on composite indices such as the SLE
        Responder Index (SRI) represent a valuable attribute for an emerging
        therapy. Payer opinion likely reflects the fact that SRI response
        represents several disease activity indices combined into a single end
        point."

About Decision Resources Group

Decision Resources Group offers best-in-class, high-value information and insights on critical issues within the healthcare industry. Clients rely on this analysis and data to make informed decisions. Find out more at www.DecisionResourcesGroup.com.

All company, brand, or product names contained in this document may be trademarks or registered trademarks of their respective holders.

For more information, contact:

Decision Resources Group

Christopher Comfort

781-993-2597

ccomfort@dresourcesgroup.com

Logo – http://photos.prnewswire.com/prnh/20130103/MM36768LOGO

SOURCE Decision Resources Group


Source: PR Newswire



comments powered by Disqus