Thought leaders are Optimistic that Emerging Therapies for Previously Treated EGFR-Mutation-Positive NSCLC will Offer Competitive Advantages over Currently Available Treatments
Improvements in Key Efficacy Endpoints, Especially Overall Survival, are Pivotal Drivers for Prescribing, According to a New Report from Decision Resources Group
BURLINGTON, Mass., April 29, 2014 /PRNewswire/ — Decision Resources Group finds that interviewed oncologists’ are optimistic that Boehringer Ingelheim’s second-generation irreversible EGFR tyrosine kinase inhibitor (TKI) Gilotrif/Giotrif will offer efficacy and delivery advantages over currently available agents for the second- and subsequent-line treatment of EGFR-mutation-positive non-small cell lung cancer (NSCLC). Interviewed oncologists’ are also optimistic that the third-generation EGFR TKIs CO-1686 (Clovis oncology/Celgene) and AP-26113 (Ariad pharmaceuticals) will offer competitive advantages in efficacy, safety and tolerability and delivery attributes.
Other key findings from the DecisionBase report entitled NSCLC (EGFR-Mutation-Positive; Previously Treated): Are Emerging Targeted Therapies Poised to Fill the Significant Unmet Need of Patients in the Second and Subsequent Lines of Therapy?:
-- The effect of an emerging therapy on key efficacy endpoints, including progression-free survival and median overall survival (MOS), has the most influence over surveyed U.S. and European oncologists' prescribing decisions for previously treated, EGFR-mutation-positive NSCLC. -- The majority of surveyed managed care organization (MCO) pharmacy directors are receptive of emerging therapies that offer improvements in MOS for the treatment of this patient population. -- Based on key thought leader's opinions, Gilotrif/Giotrif, CO-1686 and AP-26113 could all offer a level of MOS that, according to surveyed U.S. MCO pharmacy directors, would be necessary for inclusion on MCO formularies. -- Interviewed experts are enthusiastic about the third-generation EGFR TKIs CO-1686 and AP-26113 and consider them to have the strongest clinical profiles among the current and emerging therapies for previously treated, EGFR-mutation-positive NSCLC.
Comments from Decision Resources Group Analyst Jennifer Bamford:
-- "Current second- and subsequent-line treatment of EGFR-mutation-positive NSCLC consists of chemotherapy regimens, which typically result in low tumor response rates and short progression-free intervals. Based on interviewed physicians and available clinical data the second- and third-generation EGFR TKI inhibitors are set to fulfill this unmet need." -- "The anticipated future approval of the second- and third-generation EGFR TKIs for EGFR-mutation-positive patients will further advance the personalized treatment approach in NSCLC."
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