Artificial Pancreas can Prevent the Development of Hypoglycemia
The Lancet reports that using an artificial pancreas system overnight can
significantly reduce the risk of nocturnal hypoglycemia in children and
adolescents with type 1 diabetes.(1) Moreover, the first clinical trial of an
artificial pancreas system delivering both insulin and glucagon has shown
that this system can prevent development of hypoglycemia.(2) The latest issue
of the journal Diabetic Hypoglycemia (http://www.hypodiab.com) reviews
advances in artificial pancreas design and production in further detail.
the Lancet paper(1) discusses developments in the field of closed-loop
insulin delivery and reviews system components and challenges to the
introduction of this technology into clinical practice, including the need
for superfast-acting insulin analogs, dual hormone approaches to accelerate
insulin absorption, and optimization of the clinical infrastructure to
support the use of closed-loop systems.
developments supporting diabetes self-management have so far failed to lead
to major improvements in glycemic control or to consistently reduced rates of
severe hypoglycemia. He explains that one reason may be the requirement for
patients to estimate both basal and prandial insulin doses, which can be
demanding for many patients and may lead to ineffective diabetes
self-management. Professor Heller discusses how the introduction of
closed-loop systems might address this issue.
(1) Hovorka R, Allen JM, Elleri D, et al. Manual closed-loop insulin
delivery in children and adolescents with type 1 diabetes: a phase 2
randomised crossover trial. The Lancet 2010:375(9716):743-51.
(2) El-Khatib FH, Russell SJ, Nathan DM, et al. A Bihormonal Closed-Loop
Artificial Pancreas for Type 1 Diabetes. Sci Transl Med 2010:2(27):27ra27,
About Diabetic Hypoglycemia
Published by ESP Bioscience (Sandhurst, UK), Diabetic Hypoglycemia is an
influential online diabetes journal led by Editor-in-Chief Professor
provides an interactive forum for the sharing of practical knowledge and
opinions in the field of hypoglycemia.
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