Heptares and Takeda Initiate Drug Discovery Collaboration Focused on GPCR Linked to CNS Disorders
– Deal Includes
Heptares Therapeutics and Takeda Pharmaceutical Company today announced
the formation of a two-year drug discovery collaboration focused on a single
G-protein coupled receptor (GPCR) that plays an important role in the
pathology of central nervous system disorders. This GPCR has proved
intractable using historical drug discovery efforts, due to its instability
when removed from cell membranes and the resulting lack of insight into its
structure. A new medicine targeting this GPCR would be first-in-class.
During the collaboration, Heptares will leverage its proprietary StaR(R)
(stabilised receptor) technology to engineer the first-ever thermally
stabilised forms of the GPCR as the basis for the drug discovery programme.
Heptares will also apply advanced structural biology[*1] and rational drug
design approaches[*2] – including Biophysical Mapping(TM), X-ray
crystallography and fragment screening – to characterise the GPCR’s structure
and to generate early leads. Takeda will participate in lead generation and
then assume responsibility for preclinical development and clinical
development of new drugs candidates.
Under the terms of the agreement, Takeda receives worldwide commercial
rights to new drugs emerging from the collaboration. Upon signing, Heptares
received an upfront payment of
stake of approximately
wholly-owned subsidiary of Takeda. Heptares is also eligible to receive
future milestone payments of up to
product sales. Further terms of the agreement are not being disclosed.
“We are excited to be collaborating with Takeda to unlock a key GPCR
target for treating CNS disorders, an area of significant unmet medical need
where Takeda has established a leading scientific and commercial position,”
internal pipeline of GPCR-targeted medicines, we also plan to pursue
attractive external opportunities, such as this partnership with Takeda, to
extend our technology broadly across the GPCR universe.”
“The Heptares StaR(R) technology is a powerful new capability for
discovering GPCR-targeted drugs and we look forward to applying it to a
specific GPCR target of interest to Takeda in the area of neuroscience,” said
“The Heptares platform applies broadly to the GPCR target family and delivers
stabilised forms that most precisely capture the pharmacological
conformations of GPCRs as they exist in their natural cellular environments.”
[*1] Structural biology is the combined use of molecular biology and
biophysical technologies, in particular X-ray crystallography, for the
elucidation of three-dimensional structures of biological macromolecules,
[*2] Rational drug design approaches apply structural biology to
understand in atomic detail how compounds interact with their target
receptors, so they can be systematically turned into viable drug candidates
by iterative medicinal chemistry.
[*3] For future milestone payments, Heptares is eligible to receive
(GBP) in research-stage milestones and
milestones. To report the total future milestone payments in the single
currency of GBP, the figure reported above of
About Heptares Therapeutics
Heptares is a drug discovery company creating new medicines targeting
G-protein-coupled receptors (GPCRs). The Company is currently leveraging its
GPCR expertise and proprietary StaR(R) technology to build a pipeline of
best-in-class and first-in-class GPCR-targeted medicines for the treatment of
CNS, metabolic and other diseases.
GPCRs represent the single most important family of drug targets in the
human body, yet, due to their inherent instability when removed from cell
membranes, little or no structural information about these valuable targets
has been available to drive structure-based drug discovery programmes.
Heptares’ StaR(R) (Stabilised Receptor) technology enables the first-ever
thermo-stabilisation of GPCRs. This breakthrough allows Heptares scientists
to resolve GPCR structures and deploy structure-based drug discovery
techniques to identify potent and selective drug candidates to previously
Heptares has raised more than
Clarus Ventures, MVM Life Science Partners and Novartis Option Fund.
About Takeda Pharmaceutical Company
its main focus on pharmaceuticals. As the largest pharmaceutical company in
strive towards better health for patients worldwide through leading
innovation in medicine. Additional information about Takeda is available
through its corporate website, http://www.takeda.com.
Contact Information: Heptares Therapeutics Ltd +44(0)1707-358-629 Dr Malcolm Weir, CEO firstname.lastname@example.org Dr Barry Kenny, CBO email@example.com Citigate Dewe Rogerson (For Heptares) +44(0)20-7282-2948 Dr Mark Swallow, Dr Chris Gardner firstname.lastname@example.org Takeda Pharmaceutical Company Mihoko Shinomiya +81-3-3278-2037
SOURCE Heptares and Takeda