Nutri-Med Logic Corp States that EPA and DHA of Omega-3, not Î±-Linolenic Acid (ALA), are the Focus of the Recent Studies in Metabolic Syndrome.
Nutri-Med Logic Corp states that recent studies for Omega-3 shifts the focus to the end components of Omega-3 fatty acids (DHA and EPA) rather than to its precursor Ãž±-Linolenic Acid (ALA) “probably due to the relatively inefficient conversion of ALA to EPA and DHA in humans”, at the least in the case of Metabolic Syndrome.
Miami, Florida (PRWEB) August 14, 2011
Nutri-Med Logic Corp: Recent studies on effect and emerging action of Omega-3 in Metabolic Syndrome, cited in Progress in Lipid Research 2011 Jul 3;50(4):372-387, questions the efficiency of Ãž±-Linolenic Acid conversion to EPA and DHA and, in our opinion, falls just short of recommending direct supplementation of EPA and DHA as a more efficient dietary source of Omega-3.
The term Omega-3 refers to a chain of fatty acids that starts with Alpha-linolenic Acid (ALA) and ends in Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA). EPA and DHA are the two beneficial end- results of Omega-3 for the body.
ALA is mostly found in plants and seeds and DHA/EPA in cold water fishes. In the human body ALA is converted to EPA and DHA. However, the enzymes that permit the conversion of ALA to EPA & DHA also convert Linoleic Acid (Omega-6) to Arachidonic Acid, which is abundant in red meat and also found in most plants and seeds.
Metabolic Syndrome, which includes insulin resistance, increases the risk of cardiovascular diseases as well as Diabetes. According to International Diabetes Federation, 20-25% of the world population have Metabolic Syndrome.
Inflammation play an important part in Metabolic Syndrome. High-sensitivity C-reactive protein (hs-CRP), an inflammation marker, is used to predict coronary vascular diseases in Metabolic Syndrome (1). The role of inflammation as a key element in Metabolic Syndrome / insulin resistance has been well documented (2).
Additionally, animals studies and evidence from prospective longitudinal of studies in humans have also shown a relationship between subclinical inflammation and Diabetes (3).
Omega-3 diets have been suggested to decrease the risk of Diabetes in Metabolic Syndrome. It has been suggested that increased intakes of Omega-3 improves the defects in insulin signaling, seen in Metabolic Syndrome / Insulin resistance, and also to prevent alterations in glucose (sugar) homeostasis (4).
In addition stress, also, play a key role in suppressing hormones that is highly important for insulin sensitivity. Stress produces a hormone called cortisol (glucocorticoids) and cortisol causes the inhibition of adiponectin, an anti-inflammatory hormone that increases insulin sensitivity, reduces triglycerides and improves glucose metabolism (5).
Cortisol inhibition of adiponectin, in human, has been shown by both exogenous administrations to healthy subjects and endogenous cortisol hyper-production. Levels of adiponectin is negatively affected by levels of cortisol (6).
Studies by the American Heart Association showed that EPA and DHA (Omega-3) increased the circulating adiponectin (7).
Adponectin increases insulin sensitivity, reduces triglycerides and improves glucose metabolism.
A diet rich in Omega-3 is very beneficial in the cases of Metabolic Syndrome. However, nutrients cannot and should not be a substitute for medications. At the same time, it is not a secret that proper nutrients improve the overall health and thus confer valuable benefits.
It is also very important to note that these studies have not been evaluated by The FDA and, thus, one should not relate the cause of Metabolic Syndrome to the lack of the fatty acids of Omega-3 nor equate supplementation of Omega-3 to prevention, treatment or cure.
In conclusion, Nutri-Med Logic Corp. agrees with the Article of Progress in Lipid Research. However, Omega-3 has two components and each component play a key anti-inflammatory role. DHA of Omega-3 offers beneficial properties mainly for the brain, nervous system and the eyes and EPA of Omega-3 offers beneficial properties in cardiovascular system. Therefore a Balanced Omega-3 is even more suitable dietary source of Omega-3, as it would offer EQUAL benefits of Omega-3 to the 100% of the body.
Nutri-Med Logic Corp is a producer of dietary supplements that would be Essential in countering stress, inflammation, redox imbalance and hypomethylation “The Four Factors”; all of which affect the homeostasis of the body.
1. Journal of Gastroenterology. 2009, 44 (4): 313″“21
2. Inflammation. 2011, Aug 2
3. Diabetes Care. 2009 Apr;32(4):680-2
4. American Journal of Clinical Nutrition. 2006 Jun;83(6 Suppl):1499S-1504S
5. Clinical Medicine (Medicina clinica). 2005 Mar 19;124(10): 388-95.
6. Steroids. 2010 Dec;75(12):853-8. Epub 2010 May 13
7. Circulation. 2008;118:S_542. (2008 American Heart Association, Inc.)
For the original version on PRWeb visit: http://www.prweb.com/releases/prweb2011/8/prweb8717979.htm