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Research and Markets: Obesity Drug Discoveries: What the Future Holds + Obesity Tracker

Posted on: Thursday, 6 September 2007, 12:06 CDT

Research and Markets (http://www.researchandmarkets.com/reports/c67572) has announced the addition of Obesity Drug Discoveries: What The Future Holds + Obesity Tracker from Espicom Business Intelligence to their offering.

While only recently identified as a major health concern, obesity levels have been growing steadily and the condition threatens to rank among the biggest causes of premature death in both the industrialised and emerging economies. With only three products approved worldwide for long-term treatment, and growing unmet clinical need, the treatment of obesity could present a major opportunity area for pharma companies.

Key areas addressed:

-Sales forecasts for major launched products

-Obesity prevalence and trends

-Detailed appraisal of 20 therapies in research

-Estimation of launch

-Emerging trends and developments

-Focus on leading strategies

-Beta3 adrenergic receptor modulators

-Cannabinoid receptor modulators

-Digestive inhibitors/lipid metabolism modulators

-Histaminergic system modulators

-Hormone analogues

-Monoamine reuptake inhibitors/5-HT receptor modulators

-Neuropeptide receptor modulators

-Combination therapies

Content Outline:

Foreword

Executive summary

What is obesity?

Prevalence of obesity

The obesity therapy market

Obesity management

Recently-terminated programmes

The future of obesity treatment

Conclusions

Obesity has reached epidemic proportions worldwide. With 2005 estimates of approximately 1.6 billion adults (aged 15 years and over) overweight and at least 400 million adults obese, the World Health Organization predicts that by 2015, approximately 2.3 billion adults will be overweight and more than 700 million will be obese. These estimates do not even take into account a lower overweight threshold set for Asians. In the US and Canada half of all adults are likely to be obese within eight years, with only one in five people of healthy weight.

The market for weight-loss drugs in the US, Europe and Japan totalled around US$600 million in 2005, and is expected to rise globally to approximately US$2 billion by 2010. Current long-term treatments include: Abbott's Meridia/Reductil (sibutramine), a monoamine reuptake inhibitor that is approved in the US and Europe; Roche's Xenical (orlistat), a gastric lipase inhibitor that is approved in the US and Europe; and sanofi-aventis' Acomplia (rimonabant), a cannabinoid type 1 receptor blocker that is approved only in Europe.

No single major company dominates the obesity drug market, although sanofi-aventis, GSK, Merck & Co and Pfizer all have several compounds in development. The rewards are high for those who can bring effective treatments to market, but questions remain...

What are the strengths and weaknesses for current therapy approaches?

Which research approach is likely to achieve best clinical and commercial results and when are the resulting drugs likely to reach the market?

What are the development and regulatory challenges companies must overcome? The answers to these and many other questions can be found in this new 120+ page strategic management report Obesity Drug Discoveries: What the future holds (published August 2007). The web edition of the report includes, Obesity Tracker, an online news service for those needing to monitor this developing area. The report is also available in print and pdf formats.

The race is on among competing research strategies.

Obesity offers pharmaceutical companies a marketplace characterised by rapid and continuing growth, long-term unmet clinical need and a wide prevalence profile. The recognition of obesity as a serious global issue is relatively recent, and rising concern and interest has outpaced the industry's ability to nurture products through the lengthy regulatory process.

Health payers will have to balance the cost of obesity treatment with the very real health benefits of reducing related conditions, such as diabetes and cardiovascular disease. With pressure to contain rising drug costs, arguments about paying for this "lifestyle" illness are bound to rage.

Furthermore, patient demand for drug-based intervention, even for those with a questionable clinical need, could significantly boost the market value.

Although 25 companies have products in clinical development, much interest lies in the research and prospects of big pharma companies such as GSK, sanofi-aventis, Merck & Co and Pfizer. However, in such a fledgling market, the opportunities for innovation to win through are better than in established and more exploited therapy areas.

UNIQUE COMPETITIVE ASSESSMENT SCORE

For each product reviewed, the report provides a critical competitor ratio analysis, based on our assessment of the following five criteria:

Novelty/rationale for mechanism of action;

Proof of concept/clinical data;

Management expertise;

Competition within the marketplace; and, risks associated with drug development in the therapeutic class.

Products Mentioned:

869682

GSK

AVE1625

sanofi-aventis

cetilistat

Alizyme/Takeda

Contrave

OREXIGEN Therapeutics

CP-945,598

Pfizer

Empatic

OREXIGEN Therapeutics

KRP-204

Kyorin

liraglutide

Novo Nordisk

lorcaserin

Arena Pharmaceuticals

OBE101

OBEcure

obinepitide

7TM Pharma

pramlintide

Amylin Pharmaceuticals

pramlintide combination therapies

Amylin Pharmaceuticals

PYY3-36

Nastech Pharmaceutical

Qnexa

VIVUS

S-2367

Shionogi

SLV319

Solvay/BMS

taranabant

Merck & Co

tesofensine

NeuroSearch

For more information visit http://www.researchandmarkets.com/reports/c67572.

Source: Business Wire

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