September 14, 2011

Genotyping Hepatitis C Patients Improves Prediction Of Treatment Response

Press release from PLoS Medicine

In this week's PLoS Medicine, David Booth of the University of Sydney, Australia and colleagues show that genotyping hepatitis C patients for the IL28B, HLA-C and KIR genes substantially improves doctors' ability to predict whether or not patients will respond to antiviral treatment.

The results of the study suggest that an interaction between IL28B, HLA-C and KIRs provides a mechanism for hepatitis C viral control and highlight new insights into how the drug combination of pegylated interferon alpha and ribavirin clears hepatitis C virus infections, findings that may lead to improved therapies in the future. The findings have yet to be confirmed in patients of non-European descent.


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