October 26, 2011
Regulatory Process For Organ Scaling Discovered
A new study has shed light on the process by which fruit flies develop with their body proportions remaining constant. The study, conducted by the research group of Professor Markus Affolter at the Biozentrum of the University of Basel and Sven Bergmann's group at the Department of Medical Genetics, University of Lausanne, has demonstrated that the morphogen Dpp and the feedback regulator Pentagone are key factors responsible for proportional tissue growth in wings of a fruit fly. This process keeps the body plan of the fruit fly Drosophila constant. Their research results, published October 25 in the online, open-access journal PLoS Biology, might also be important for organ growth in other organisms.
One of the most interesting and perhaps mysterious questions in developmental biology is to understand how organisms develop from an embryo to an adult with their body proportions remaining constant over generations. External factors such as nutrition and temperature generally impact the overall size of an organism, but leave body proportions unaffected. Fish kept in too small aquaria, for example, just grow proportionally smaller and flies kept under starving conditions have proportionally smaller heads, abdomens, legs and wings. The phenomenon of keeping proportions during growth is called 'scaling' and has been subject of study for decades. Indeed, how scaling is achieved has, until recently, not been very well understood.
Affolter's and Bergmann's groups used the wing of the fruit fly Drosophila as a model to study scaling quantitatively during growth. Similar to the micro-macro link — a term used in social sciences — scaling is defined as the preservation of proportions of gene expression domains with tissue size during growth. In other words, proportions found on the micro-level of gene expression are found on the macro-level of wing formation. "Better insight into the molecular control of scaling will have large consequences for the understanding of how nature has developed such robust body plans", explains Affolter.
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