Newly Released, Groundbreaking Research Studies Show USPlabs’ DMAA Supplements are Safe and Effective
DALLAS, Dec. 8, 2011 /PRNewswire-USNewswire/ — Four new medical research studies published today and one more to come confirm that the best-selling supplements produced by USPlabs, Jack3d and OxyElite Pro, which contain DMAA, are safe and do not cause adverse health effects when used as directed, according to the research on DMAA conducted by a leading medical expert on nutritional supplements.
The groundbreaking, peer-reviewed studies on the DMAA products were performed at an esteemed cardiorespiratory laboratory at a Division I, U.S. university by one of the nation’s leading and most respected experts on nutritional supplements.
The release of these studies places both Jack3d and OxyElite Pro in the top 1% for volume of medical research performed on finished dietary supplements. The studies were undertaken in order to reiterate the safety of products containing DMAA through medical research and the results show that DMAA-containing products can be a safe and effective part of a healthy workout regimen.
The results of the studies are as follows.
In a randomized, double-blind and placebo-controlled trial with crossover, OxyElite Pro was shown to increase markers of lipolysis (fat breakdown) and energy expenditure (metabolic rate) in a group of six healthy men and six healthy women, all of whom were exercise-trained individuals.
Specifically for the markers of lipolysis, glycerol was increased by an average of 29% and 65% over baseline in men and women, respectively, 120 minutes after ingesting two capsules of OxyElite Pro. Free fatty acids were increased by an average of 92% and 68% in men and women, respectively. Finally, energy expenditure was increased by an average of 9% and 24% in men and women, respectively.
These data indicate that by increasing lipolysis and metabolic rate, the DMAA-containing OxyElite Pro may allow for reduced fat mass and weight loss.
In a randomized, double-blind, placebo-controlled trial, OxyElite Pro was studied to see if it could improve body composition in healthy men and women over an eight-week period of use. A group of 32 exercise-trained men and women participated in the study. When comparing baseline values with those after eight weeks of use, subjects in the OxyElite Pro group were found to have decreased body weight, BMI, waist size, waist to hip ratio, total body fat percentage, fat mass and appetite.
In addition to efficacy, safety of the DMAA-containing product was also assessed via hemodynamic and metabolic variables. While OxyElite did increase heart rate by an average of six beats per minute (comparable to the effect seen in some studies after the administration of caffeine dosages equivalent to 2 or 3 cups of coffee), no changes in blood pressure were noted when comparing the values seen at baseline to those after eight weeks of use. In addition, liver and kidney function were not affected as indicated by various blood borne markers. The supplement was well-tolerated and no serious adverse events were noted.
In looking at the product’s efficacy, men experienced an average 1.16% reduction in body fat percentage while women experienced an average decrease of 0.8%. Men experienced a 1.24 inch reduction in their waist size from baseline, while women lost 0.78 inches. Men also lost 0.92 inches off their hips while the women’s hip sizes didn’t change, indicating an improvement of the waist-hip ratio.
In addition, when subjects were asked to rate their appetite on a scale of 1-10 from baseline until week eight of the study, they reported an average decrease in appetite scores of approximately 24% after using OxyElite Pro.
Overall, this eight-week study corroborated what the previous acute study indicated, which is that by increasing lipolysis and metabolic rate, OxyElite Pro is able to reduce fat mass in healthy men and women.
In an open-label, single-arm trial consisting of seven healthy men, each was instructed to consume the DMAA-containing Jack3d each day for two weeks. At the beginning and end of the study, blood pressure, heart rate and various indicators of renal and liver function were assessed. The study found that there were no statistically significant changes from baseline to the end of the study. Jack3d, which contains DMAA, was well tolerated and no serious adverse events were noted.
In addition to these data, the hemodynamic response to acute ingestion was assessed as well for this DMAA product. Although small and transient changes in blood pressure were noted, these changes were consistent with changes seen after administration of the equivalent of 2-3 cups of coffee. Jack3d did not result in a statistically significant change in heart rate or blood pressure.
In an open-label, single-arm trial consisting of four men and two women, subjects were instructed to consume OxyElite Pro each day for two weeks. At the beginning and end of the study, blood pressure, heart rate and various indicators of renal and liver function were assessed. The study found that there were no statistically significant changes from baseline to the end of the study. No serious adverse events were noted.
In addition to these data, the hemodynamic response to acute ingestion was assessed as well. OxyElite Pro did not result in a statistically significant change in heart rate or diastolic pressure, but did cause a statistically significant change in systolic blood pressure; this increase was mild and transient and yet again, was similar to the increase seen in subjects ingesting an amount of caffeine equivalent to 2-3 cups of coffee.
In addition, a ten-week safety study on the DMAA-containing Jack3d has been submitted for publication. This study evaluated heart rate, blood pressure and various measures of metabolic function (e.g., liver and kidney function) and found no changes from baseline to the end of the study. Jack3d was well tolerated and no adverse effects were noted.