Silence Therapeutics Additional Listing
LONDON, December 20, 2011 /PRNewswire/ –
Silence Therapeutics plc [http://www.silencetherapeutics.com ] (AIM: SLN) (“Silence”
or the “Company”) a leading global RNA
[http://silence-therapeutics.com/content/scienceofrnai/overview.htm ]interference (RNAi)
therapeutics company, today announces that application has been sought for 530,000 new
ordinary shares of 1 pence each (“Ordinary Shares”) to be admitted to trading on AIM. The
new Ordinary Shares are being issued in accordance with a contractual agreement with Dr.
Philip Haworth, former Chief Executive Officer of Silence.
It is expected that dealings in the new Ordinary Shares, which will rank pari passu in
all respects with the existing issued share capital of the Company, will commence on 21
Notes for editors
About Silence Therapeutics plc (http://www.silence-therapeutics.com)
Silence Therapeutics plc (AIM: SLN) is a leading biotechnology company dedicated to
the discovery, development and delivery of targeted, systemic RNA interference (RNAi)
therapeutics for the treatment of serious diseases. Silence offers one of the most
comprehensive short interfering RNA (siRNA) therapeutic platforms available today based on
a strong intellectual property portfolio and large clinical safety database. Silence’s
clinical siRNA product pipeline is one of the broadest in the industry.
The Company possesses multiple proprietary siRNA delivery technology platforms
including AtuPLEX(TM), DACC and DBTC. AtuPLEX enables the broad functional delivery of
siRNA molecules to targeted diseased tissues and cells, while increasing their
bioavailability and intracellular uptake. The DACC delivery system allows functional
delivery of siRNA molecules selectively to the lung endo-thelium with a long duration of
target mRNA and protein knock-down. The DBTC delivery system enables functional delivery
of siRNA molecules selectively to liver cells including hepatocytes.
Additionally, the Company has a platform of novel siRNA molecules based around its
AtuRNAi chemical modification technology, which provides a number of advantages over
conventional siRNA molecules. Silence’s unique RNAi assets also include structural
features for RNAi molecules and specific design rules for increased potency and reduced
off-target effects of siRNA sequences.
The Company’s lead internal drug candidate is Atu027, a liposomal formulation in
clinical development for systemic cancer indications and one of the most clinically
advanced RNAi therapeutic candidates in the area of oncology. Atu027 incorporates two of
the Company’s technologies, AtuRNAi and AtuPLEX(TM). Silence is currently conducting an
open-label, single-centre, dose-escalation Phase I study with Atu027 in patients with
advanced solid tumors involving single, as well as repeated, intravenous administration.
Encouraging interim safety and pharmacokinetic data were presented at the American Society
of Clinical Oncology Annual Meeting in June 2011. The study is expected to be completed in
the first half of 2012.
The Company’s RNAi therapeutic platform has received key validation through multiple
partnerships with pharmaceutical companies including AstraZeneca, Dainippon Sumitomo,
Pfizer/Quark, and Novartis/Quark. Silence is actively pursuing the establishment of
additional partnerships. Silence Therapeutics has operations in both Berlin and London.
For further information, please contact: Silence Therapeutics Thomas Christely/Max Herrmann +49-30-9489-2800/+44-20-7491-6520 email@example.com firstname.lastname@example.org M:Communications (Europe) Peter Laing / Emma Thompson / Claire Dickinson +44-20-7920-2345 / +44-20-7920-2342 email@example.com Singer Capital Markets Shaun Dobson/Claes Spang +44-20-3205-7500 firstname.lastname@example.org email@example.com
SOURCE Silence Therapeutics Plc