December 26, 2011

A Shot at Reducing HPV

(Ivanhoe Newswire) — Mathematical models used to investigate whether vaccinating females only, males only, or both sexes is the best way to achieve reduction in the prevalence of sexuality-transmitted infections.

For human papillomavirus (HPV), the authors found that single-sex vaccination was the most effective strategy for prevention of disease and that it was preferable to vaccinate the sex with the highest pre-vaccine prevalence of HPV infection which for HPV is females.

"Our results provide a justification, under most circumstances, for the intuitively plausible strategy of targeting intervention at the subgroups that harbor most infections and that act as a reservoir for transmission“¦We show that, once routine vaccination of one sex is in place, increasing the coverage in that sex is much more effective in bolstering herd immunity than switching to a policy that includes both sexes," the authors were quoted as saying.

SOURCE: PLoS Medicine, December 23, 2011