January 9, 2012

Time Heals All Wounds

(Ivanhoe Newswire) — Give it time, time heals all wounds, these words of wisdom are true when it comes to healing. As healing progresses, the need to grow new blood vessels is critical to providing nutrients and oxygen; however, it takes time to grow these necessary blood vessels.

Wound healing requires complex interactions between cells resident at the damaged site and infiltrating immune cells. Endothelial progenitor cells (EPCs) are cells that come from the bone marrow and are they key to the production of new vessels.

Toshikazu Kondo and colleagues at Wakayama Medical University, in Wakayama, Japan, demonstrated that the chemokine CCL5 helps to direct the recruitment of EPCs to sites of wounding by acting on the chemokine receptor CCR5. These findings suggest that humans who carry mutations in CCR5 may also experience problems with wound healing, and identify the CCR5/CCL5 as a potential clinical target to promote healing.

SOURCE: Journal of Clinical Investigation, January, 2012