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Last updated on April 16, 2014 at 1:21 EDT

LEO Pharma A/S In-Licenses Promising Compound From Virobay Inc. for Oral Treatment of Psoriasis

January 9, 2012

BALLERUP, Denmark, January 9, 2012 /PRNewswire/ –

LEO Pharma A/S, a global pharmaceutical company specializing in dermatology, has
entered into a multi-million dollar collaboration with the US biotech company Virobay Inc.
to develop an oral treatment for psoriasis.

(Logo:
http://www.newscom.com/cgi-bin/prnh/20110606/460992 )

(Logo:
http://www.newscom.com/cgi-bin/prnh/20120109/502540 )

The pharmaceutical company LEO Pharma A/S has signed an in-licensing deal with the US
biotech company Virobay Inc. to develop an oral treatment for psoriasis. The in-licensing
deal concerns an innovative compound which has the potential to be the first on the market
with its specific mode of action. The deal involves an upfront payment to Virobay of USD
7m, followed by milestone payments totaling up to USD 300m and tiered royalties.

The compound is currently being tested in preclinical studies. Phase I studies will be
launched in Q4 2012, and testing on psoriasis patients is planned for Q1 2013. A limited
number of oral psoriasis treatments are already on the market, but they have potential
drawbacks in terms of adverse effects and a need for monitoring. A safe and convenient
oral treatment thus addresses a significant unmet patient need.

“Virobay’s expertise with this compound is outstanding internationally. Combined with
LEO Pharma’s expertise in dermatology and drug development, we are the perfect match to
develop this innovative compound further. Together with Virobay, we pursue new scientific
findings and not least, strive to develop a safe, effective and convenient oral
treatment,” comments Kim Kj0ller, Senior Vice President, Global Development, LEO Pharma.

For Virobay, the deal represents a valuable opportunity for the small drug discovery
company to work with an industry heavyweight.

“Collaborating with LEO Pharma makes it possible for us to conduct testing in a
clinical program with world-leading dermatologists. The compound’s possible indications
cover a range of dermatological diseases and co-morbidities. However, first and foremost
we hope to develop a safe oral treatment for the 125 million or so people worldwide who
suffer from psoriasis,” states Robert Booth, founder and CEO of Virobay.

More deals are expected in the future

The scientific collaboration with Virobay is the latest milestone in LEO Pharma’s
ambitious global growth strategy. More acquisitions and in-licensing deals are expected in
the future as well as investments in internal drug discovery.

“We are actively seeking out new opportunities to expand our pipeline. Virobay’s
compound is a strong asset which will drive our innovation forward. The next steps take
place in the laboratories where our researchers will work hard together to achieve new
innovative solutions to dermatologic diseases,” adds Kim Kj0ller.

About Virobay Inc.

Founded in 2006, Virobay is a leader in the design, synthesis and development of small
molecule inhibitors of cysteine proteases, a diverse class of enzymes that are key
mediators in a variety of diseases, including autoimmunity, neuropathic pain, liver
disease, cancer and cardiovascular disorders. Virobay’s clinical pipeline currently
includes product candidates in autoimmune disease, neuropathic pain and liver fibrosis.
For more information, please visit http://www.virobayinc.com.

About LEO Pharma A/S

Founded in 1908, LEO Pharma is an independent, research-based pharmaceutical company.
LEO Pharma develops, manufactures and markets pharmaceutical drugs for dermatologic and
thrombotic patients in more than 100 countries globally. The company has its own sales
forces in 61 countries and employs more than 4,600 employees worldwide. LEO Pharma is
headquartered in Denmark and is wholly owned by the LEO Foundation. For more information,
please visit http://www.leo-pharma.com.

You may also view the company fact sheet at

http://www.leo-pharma.com/Admin/Public/Download.aspx?File=/Files/Filer/Leo_corporate_downl

oads/Leopharmafacts.pdf

Contact:

Anne Katrine N0rgaard, Corporate Communications Manager, LEO Pharma, +45-2875-4155,


    Photo: 

http://www.newscom.com/cgi-bin/prnh/20110606/460992

http://www.newscom.com/cgi-bin/prnh/20120109/502540

SOURCE LEO Pharma A/S and Virobay Inc.


Source: PR Newswire