January 27, 2012
Discovery Of New Vaccine Approach For Treatment Of Cancer
The findings were published online in Cancer Research
Scientists in Trinity College Dublin, Ireland, have developed a new vaccine to treat cancer at the pre-clinical level. The research team led by Professor Kingston Mills, Professor of Experimental Immunology at Trinity College Dublin discovered a new approach for treating the disease based on manipulating the immune response to malignant tumors. The discovery has been patented and there are plans to develop the vaccine for clinical use for cancer patients.
Professor Mills' group has developed a novel vaccine and immunotherapeutic approach that can overcome these obstacles and has the potential to significantly improve on existing technologies. The therapy is based on a combination of molecules that manipulates the immune response to curb the regulatory arm while enhancing the protective arm, allowing the induction of specialist white blood cell called killer T cells to target and eliminate the tumors. The new vaccine approach was found to be highly effective at pre-clinical stage in treating a range of cancers in murine models.
The findings were published in December online in Cancer Research, the leading journal of The American Association of Cancer Research. The research was performed by a Senior Postdoctoral Fellow Dr Neil Marshall, at Trinity College Dublin, with the help of two PhD students, Anna-Maria Corcoran and Karen Galvin and was funded by a Science Foundation Ireland Principal Investigator award to Professor Mills. The discoveries have been patent protected and Professor Mills has plans to translate them to the clinic via a TCD Campus Company, TriMod Therapeutics that he co-founded with Dr Jeremy Skillington.
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