February 10, 2012
Metastatic Breast Cancer Hitches A Free Ride From The Immune System
Inflammatory breast cancer (IBC) is the most lethal form of breast cancer. It spreads easily through the lymphatic and blood vessels, forming metastasis which can lead to multi-organ failure. New research published in BioMed Central's open access journal Cell Communication and Signaling demonstrates how IBC cells use IL-8, secreted as part of the anti-inflammatory response by a specific set of white blood cells (monocytes), to increase fibronectin expression.
Fibronectin is a cell-adhesion molecule which is usually involved in wound healing and cell migration during embryogenesis. Over-expression of this molecule is thought to allow cancer to metastasize. Prof Mona Mohamed from Cairo University used a cytokine antibody array to identify which immune-regulating molecules (cytokines, chemokines, and growth factors) were secreted by monocytes and found that, while monocytes secreted a small amount each of a wide range of molecules, there was up to 10 times more IL-8 and MCP-1.
The monocyte cocktail did not alter expression of another cell adhesion molecule, E-cadherin. Prof Mohamed continued, "From what we already knew about cell adhesion and these results, it seems that IBC cells are held together in clumps by E-cadherin, but fibronectin, and the IL-8 signaling pathway, are involved in branching and invasion necessary for metastasis of IBC."
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