February 27, 2012
Homocysteine and Coronary Heart Disease
(Ivanhoe Newswire) -- Previous studies have suggested that levels of the amino acid, homocysteine, might be an adjustable risk factor for coronary heart disease. However, a recent comprehensive study has found that high blood levels of homocysteine have no meaningful effect on coronary heart disease risks. This makes the previous suggestion of lowering homocysteine with folate acid unbeneficial.
The comprehensive study is made up of 19 unpublished and 86 published studies. The analysis shows that in approximately 50,000 people who have coronary heart disease and 68,000 controls, people who had the MTHFR gene (MTHFR gene is responsible for methylene tetrahydofolate reductase, that uses folate acid to break down and remove homocysteine) that is associated with 20 percent higher blood homocysteine did not have an increase in risk for coronary heart disease.
Source: PLoS Medicine, February 2012