March 6, 2012
High Blood Glucose Levels May Increase Kidney Disease In Elderly Populations
New study shows high insulin resistance is correlated with rapid decline in renal function
Elderly people with the metabolic syndrome–defined as having multiple risk factors associated with developing diabetes and heart disease–had an increased risk of chronic kidney disease, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
"Our study found that metabolic syndrome predicts both the prevalence and incidence of chronic kidney disease in people aged 65 years or older," said lead investigator Chung-Jen Yen, MD, of National Taiwan University in Taipei, Taiwan. "We also found that rapid decline in renal function is more likely found in individuals with insulin resistance and high blood sugar levels."
In this study, researchers sought to define the effect of the metabolic syndrome and insulin resistance on the development of chronic kidney disease, and the decline in renal function in a cohort of 1,456 Asians aged 65 years or older. Yen and his colleagues evaluated study participants for the metabolic syndrome and insulin resistance, and followed them for an average of more than three years. They found that insulin resistance may be the central hub that links metabolic syndrome and the deterioration of renal function.
"Our study suggests that people can safeguard their kidneys when they take care of their blood glucose levels and lose weight," said Yen. "Further studies are needed to assess the impact of treating metabolic syndrome and insulin resistance on renal outcomes in the elderly population."
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