March 28, 2012
Androgen suppression — the inhibition of testosterone and other male hormones — is a routine therapy for prostate cancer. Unfortunately, it can dramatically reduce the quality of patients' sex lives and, more importantly, lead to cancer recurrence in a more deadly androgen-independent form.
A new paper combining mathematical modeling with clinical data validates a different approach: cycling patients on and off treatment. Such intermittent androgen suppression alleviates most unwanted side effects and postpones the development of resistance to treatment.
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