April 26, 2012
Research Breakthrough For Drugs Via The Skin
A research team at Karolinska Institutet in Sweden has succeeded in describing the structure and function of the outermost layer of the skin — the stratum corneum — at a molecular level. This opens the way not only for the large-scale delivery of drugs via the skin, but also for a deeper understanding of skin diseases.
"You could say that we've solved the puzzle of the skin barrier, something that has great potential significance for dermatology," says principal investigator Lars NorlÃ©n, associate professor at Karolinska Institutet's Dermatology and Venereology Unit.
"We can now construct computer simulations to help us find out which substances have to be added to different drugs to open up the skin," says Dr NorlÃ©n. "We hope to one day be able to administer regular drugs like insulin and antibiotics this way."
To conduct their study, the researchers developed an entirely new experimental approach involving rapidly freezing tiny skin samples and studying them under a low-temperature electron microscope.
"This has given us an unprecedented opportunity to determine the molecular structure and function of native cells and tissues in situ without having our data muddied by the addition of dyes, solvents or plastics," adds Dr NorlÃ©n.
Their discovery has profound significance for dermatology. The majority of skin diseases manifest themselves in some kind of functional disorder of the skin's protective barrier, and the researchers now want to use their method to determine such changes at a molecular level. If they succeed in this, it will be a decisive step towards a deeper understanding of these diseases and, hopefully, the development of new, improved treatments.
"This may be a breakthrough for dermatology," says Dr NorlÃ©n. "Our team has devoted the past 20 years to unlocking the mysteries of the stratum corneum."
All land-living organisms are surrounded by a protective watertight shell. In humans and other vertebrates, it comprises a uniquely complex layer of fat between the cells of the stratum corneum.
"Understanding how this protective barrier has developed is an important step towards explaining why life on land exists and is even possible," says Dr Lars NorlÃ©n.
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