Waking Up the Brain!
(Ivanhoe Newswire) – Under some conditions, the brains of embryonic chicks appear to be awake well before those chicks are ready to hatch out of their eggs. The findings may have implications not only for developing chicks and other animals, but also for prematurely born infants.
Pediatricians have worried about the effects of stimulating brains that are still under construction, especially as modern medicine continues to push back the gestational age at which preemies can reliably survive. Researchers woke chick embryos inside their eggs by playing loud, meaningful sounds to them. Playing meaningless sounds to the embryos wasn’t enough to rouse their brains.
“This work showed that embryo brains can function in a waking-like manner earlier than previously thought—well before birth,” Evan Balaban of McGill University was quoted saying. “Like adult brains, embryo brains also have neural circuitry that monitors the environment to selectively wake the brain up during important events.”
That waking-like brain activity appears in a latent but inducible state during the final 20 percent of embryonic life, the researchers found. At that point, sleep-like brain activity patterns also emerge.
Before that major dividing line in development—for the first 80 percent of embryonic life— “embryos are in a state that is neither like sleep nor waking,” Balaban was quoted saying. He suggests it may be useful to compare that state to what happens when people are comatose or under the influence of anesthesia.
The researchers say they were surprised to capture waking-like activity before birth. And there were other surprises, too. The embryo brains they observed showed considerable variation in activity, for one.
Before the emergence of sleep and waking patterns of brain activity, the chick embryos in their study exhibited lots of spontaneous movement, even as their higher-brain regions remained inactive. Once the chicks reached that 80 percent mark in development, higher-brain regions began crackling with activity. At the same time, those physical movements ceased as the embryos entered a sleep-like state.
“The last 30 percent of fetal brain development is a more interesting time than we previously thought, because it’s when complex whole-brain functions that depend on coordination of widely separated brain areas first emerge,” Balaban was quoted syaing. “Embryos begin to cycle through a variety of brain states and are even capable of showing waking-like brain activity.”
That might explain instances of complex fetal and early neonatal learning. “It also raises questions about the longer-term developmental consequences that such brain activity may have, if it is induced before intrinsic brain wiring is sufficiently completed,” Balaban was quoted saying, “for example, in babies born very prematurely. We are excited by the possibility that the techniques developed here can now be used to provide answers to these questions.”
SOURCE: Cell Press, May, 2012