Last updated on April 19, 2014 at 21:20 EDT

Amakem Appoints Dr. Steve Pakola as Chief Medical Officer; Dr. George Lasezkay Joins Board of Directors

May 10, 2012

DIEPENBEEK, Belgium, May 11, 2012 /PRNewswire/ –

– Appointments deepen ophthalmology, product development and corporate development

Amakem NV, a kinase platform company focusing on ophthalmology, today announces the
appointment of Dr. Steve Pakola as Chief Medical Officer and Dr. George Lasezkay to its
Board as an Independent Director. Both have exceptional track records in the biotechnology
industry and bring a wealth of ophthalmology experience to Amakem.

Dr. Pakola was previously Chief Medical Officer at ThromboGenics NV (Euronext
Brussels: THR), a biopharmaceutical company focused on developing innovative ophthalmic
medicines, where he played a pivotal role in driving the development of ThromboGenics’
lead product, ocriplasmin, from initial concept through to regulatory submission.

Dr. Lasezkay was previously Corporate Vice President of Corporate Development and
Assistant General Counsel for Allergan, Inc., a global pharmaceutical and medical
aesthetics company. In these positions, he was responsible for corporate strategy as well
as licensing, R&D collaboration and acquisition transactions involving both products and
companies. George is currently an industry consultant and serves as an advisor to a number
of public and private biotechnology companies developing therapies for ophthalmic

Dr. Jack Elands, CEO of Amakem, said: “Amakem’s ability to attract a CMO and
Independent Director of the caliber of Steve and George highlights the potential AMA0076
has in glaucoma and of our ophthalmology and technology platform in general. Steve played
a key part in the successful development of ocriplasmin at ThromboGenics, while George has
been closely involved in the strategic development of businesses in ophthalmology and in
other therapeutic areas. We very much look forward to their joining the Amakem team as we
advance our own highly promising pipeline and build our company.”

Steve Pakola commented: “I am very excited by this opportunity. AMA0076 has shown
excellent preclinical results and offers the potential to be a breakthrough product for
one of the leading global causes of preventable blindness. It has given me great
satisfaction to have seen a novel ophthalmic product through from concept to regulatory
submission, and I look forward to bringing that drive and experience to Amakem.”

George Lasezkay, said: “Amakem has already made great progress with its development of
AMA0076 and the company’s Localized Drug Action platform has the potential to generate
additional high value product candidates in ophthalmology and other indications. It is an
exciting time to be joining the Board and bringing my experience to bear on the strategic
development of the business.”

Michael Palfreyman, Chairman of Amakem, said: “It is a great pleasure to welcome
George to the Board and Steve to the senior team at Amakem. Their track records speak for
themselves and their breadth of experience will be invaluable as we continue to prove the
value of the platform in ophthalmology, where AMA0076 is making excellent progress, and
explore opportunities in other therapeutic areas.”

Steve Pakola – Biography

Dr. Pakola is a physician with over 15 years of industry experience, including
experience in preclinical and clinical development, regulatory affairs and medical
affairs. Dr. Pakola was at ThromboGenics for 12 years, where he was responsible for the
Company’s worldwide clinical development programs including vitreoretinal disease and
cardiovascular disease. Dr. Pakola identified the opportunity for ocriplasmin in eye
diseases and spearheaded the development programme which has led to successful completion
of Phase III trials in symptomatic vitreomacular adhesion including macular hole and
recent filing in the US and Europe. More broadly, Dr. Pakola played a significant role in
transforming ThromboGenics from a small start-up to a publicly-traded company.

Before joining ThromboGenics, Dr. Pakola was Associate Director of Cardiovascular
Clinical Research at Boehringer Ingelheim Pharmaceuticals, Inc., where he was U.S.
Clinical Leader for Pradaxa, the first new oral anticoagulant to reach the market in 50
years. He received his B.A. with Honors in Biology and his M.D. with Honors from
University of Pennsylvania, U.S.A where he was awarded the Charles A. Oliver Ophthalmology

George Lasezkay – Biography

Dr. Lasezkay is the president of Horizon Pharma Group, a consultancy practice that
advises life sciences companies on strategy and business development.

Previously, he was Corporate Vice President of Corporate Development and Assistant
General Counsel for Allergan, Inc., a global pharmaceutical and medical aesthetics
company. In these positions, he was responsible for corporate strategy as well as
licensing, R&D collaboration and acquisition transactions involving both products and
companies. While at Allergan, he was instrumental in establishing the Allergan Ligand
Retinoid Therapeutics joint venture that was subsequently awarded the Recombinant Capital
Breakthrough Biotechnology Alliance award in 1997.

Dr. Lasezkay has served as a director of a number of US and international
biotechnology and emerging pharmaceutical companies, both public and private. He also has
extensive experience in private legal practice, hospital pharmacy practice, clinical
pharmacokinetics consultation, clinical drug research, and pharmacy education.

Dr. Lasezkay earned B.S. Pharmacy and Doctor of Pharmacy degrees from the State
University of New York at Buffalo and a J.D. degree from the University of Southern
California Law Center. He also holds a certificate in alternative dispute resolution from
the Straus Institute of Dispute Resolution of the Pepperdine University School of Law.

About Amakem

Amakem is an ophthalmology company developing new treatments for serious eye
conditions. Amakem’s product pipeline is based on its unique Localized Drug Action
platform which is designed to generate safe and effective novel kinase inhibitors that
minimize systemic exposure with the aim of reducing side effects. Amakem’s lead candidate,
AMA0076, is for glaucoma and the Company is working to apply the Localized Drug Action
approach to a range of other eye diseases.

Founded in 2010, Amakem has raised more than EUR21m in funding and is backed by
leading life sciences investors including Forbion, Credit Agricole, Vesalius BioCapital,
LRM, PMV/Vinnof and Life Science Research Partners.

Amakem is based in Belgium and located in the life sciences incubator “BioVille” at
the University of Hasselt. The Company has a long-standing collaboration with the
Ophthalmology Research Center of the University Leuven Hospital.

        For more information, please contact

        Jack Elands, CEO



        Citigate Dewe Rogerson

        Chris Gardner/Nina Enegren




Source: PR Newswire