Last updated on April 16, 2014 at 14:14 EDT

DNA Blood Test Detects Cancer Resistance Using Inostics’ BEAMing Technology

June 18, 2012

BALTIMORE, Maryland and HAMBURG, Germany, June 18, 2012 /PRNewswire/ –

Two studies published back-to-back in last week’s Nature applied DNA blood testing
using the BEAMing technology to detect drug resistance mediated by KRAS mutations in
colorectal cancer patients months before treatment failure was observed.

The group led by Alberto Bardelli, PhD of the University of Torino, Italy describes
the development of secondary resistance mutations to the anti-EGFR monoclonal antibody
cetuximab (Erbitux(R)) in patients with metastatic colorectal cancer (mCRC) [Misale S. et
al., Nature Epub 13 June 2012].The second group led by Luis Diaz, MD and Bert Vogelstein,
MD from Johns Hopkins University reached similar conclusions after studying mCRC patients
treated with a monotherapy of panitumumab (Vectibix(R)) [Diaz Jr LA et al., Nature Epub 13
June 2012].

Both teams concluded that blood-based noninvasive monitoring of patients undergoing
targeted therapy could provide significant benefits by allowing for early intervention
with additional treatment options that may delay or prevent disease progression.

The BEAMing technology is a combination of digital PCR and flow cytometry originally
developed by the group of Bert Vogelstein, MD. Inostics licensed the technology from the
Johns Hopkins University and automated it for routine use.

BEAMing is the most sensitive and quantitative technology available today for the
detection of tumor specific somatic mutations in blood samples. Inostics’ BEAMing services
are readily available to support clinical trials and research in oncology. Furthermore,
Inostics will offer BEAMing as a CLIA certified test for routine analysis.

For more information on blood testing and the BEAMing Digital PCR technology refer to
http://www.inostics.com or email us at info@inostics.com.

        Please contact:
        Friederike Lehmann, PhD
        Marketing & Licensing
        Phone +49-(0)40-413383-90
        Fax   +49-(0)40-413383-99


SOURCE Inostics GmbH

Source: PR Newswire