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Type 2 Diabetes Possibly Linked To Psoriasis

June 19, 2012

A population-based study from the United Kingdom suggests that the common skin condition psoriasis may be a risk factor for the development of Type 2 diabetes mellitus (T2DM), according to a report published Online First by Archives of Dermatology, a JAMA Network publication.

Psoriasis, a chronic inflammatory disease characterized by scaling of the skin, affects 2 percent to 4 percent of the adult population, according to the study background.

Rahat S. Azfar, M.D., of the University of Pennsylvania, Philadelphia, and colleagues used data from The Health Improvement Network (THIN), an electronic medical records database in the United Kingdom, to conduct a population-based study of adults ages 18 to 90 years with psoriasis vs. patients without psoriasis. They matched 108,132 patients with psoriasis with 430,716 patients without psoriasis.

“The adjusted attributable risk of developing T2DM among 1,000 patients with psoriasis per year is 0.9 extra cases overall, 0.7 cases in those with mild psoriasis, and 3.0 cases in those with severe psoriasis,” the authors report in the study findings.

A secondary aim of the study was to determine whether patients with diabetes and psoriasis were more likely to receive prescription diabetic therapy compared with patients with DM but no psoriasis.

“We observed no difference in use of oral hypoglycemic agents or insulin among patients with mild psoriasis; however, patients with severe psoriasis were more likely to be prescribed oral hypoglycemic agents and had a trend toward being more likely to be prescribed insulin,” the authors note.

“The data from this study suggest that psoriasis is a risk factor for the development of T2DM and that this relationship is dose dependent, with severe psoriasis conferring a higher risk than mild psoriasis,” the authors comment. “Mechanistically, this relationship may be driven by chronic inflammation because both psoriasis and T2DM are associated with elevated levels of TH1-driven inflammatory markers, and because several studies have pointed to endogenous insulin resistance in patients with psoriasis.”

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