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Last updated on April 23, 2014 at 20:10 EDT

Shire Changes its NASDAQ Ticker Symbol to SHPG

July 9, 2012

DUBLIN, Ireland, July 9, 2012 /PRNewswire/ –

Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical
company, announces that the NASDAQ ticker symbol for Shire’s American Depositary Shares
(“ADSs”) will change from “SHPGY” to “SHPG” on and from the opening of NASDAQ trading on
July 11, 2012.

Each ADS continues to represent 3 ordinary shares of Shire plc.

The London Stock Exchange ticker symbol for Shire plc’s ordinary shares remains “SHP”.

Notes to editors

SHIRE PLC

Shire’s strategic goal is to become the leading specialty biopharmaceutical company
that focuses on meeting the needs of the specialist physician. Shire focuses its business
on attention deficit hyperactivity disorder, human genetic therapies, gastrointestinal
diseases and regenerative medicine as well as opportunities in other therapeutic areas to
the extent they arise through acquisitions. Shire’s in-licensing, merger and acquisition
efforts are focused on products in specialist markets with strong intellectual property
protection and global rights. Shire believes that a carefully selected and balanced
portfolio of products with strategically aligned and relatively small-scale sales forces
will deliver strong results.

For further information on Shire, please visit the Company’s website:

http://www.shire.com.

For further information please contact:

           Investor Relations
           Eric Rojas
           erojas@shire.com
           +1-781-482-0999

           Sarah Elton-Farr
           seltonfarr@shire.com
           +44(0)1256-894157

SOURCE Shire plc


Source: PR Newswire