July 23, 2012
Prostate Cancer: Surgery vs. Observation
(Ivanhoe Newswire) — In a study reported by the New England Journal of Medicine, researchers tried to determine which course of action is more beneficial for men diagnosed with localized prostate cancer through the prostate-specific antigen (PSA) test: radical prostatectomy or observation without surgery?
From November 1994 through January 2002, researchers randomly assigned 731 men with localized prostate cancer to radical prostatectomy or observation and followed them through January 2010. The primary outcome was all-cause mortality, and the secondary outcome was prostate-cancer mortality.
Researchers concluded that radical prostatectomy did not significantly reduce all-cause or prostate-cancer mortality compared with observation through at least 12 years of follow up. Though surgery had slightly more positive effects, absolute differences were only less than 3 percentage points.
Source: New England Journal of Medicine, July 2012