Last updated on April 23, 2014 at 10:38 EDT

Dr Steven Gillis to Join Shire Board of Directors

September 4, 2012

DUBLIN, Ireland, September 4, 2012 /PRNewswire/ –

Shire plc (LSE: SHP, NASDAQ: SHPG) announces that Dr. Steven Gillis, Ph.D. will join
the Board of Directors on October 1, 2012. On joining the Board, Dr. Gillis will become a
member of the Company’s Science & Technology Committee and Remuneration Committee.

Dr. Gillis is currently a Managing Director at ARCH Venture Partners, a provider of
venture capital for technology firms, where he is focused on the evaluation of new life
science technologies and the development and growth of ARCH’s biotechnology portfolio
companies. Prior to this, Dr. Gillis was a founder and director of Corixa Corporation,
acquired by GlaxoSmithKline in 2005. Prior to starting Corixa, Dr. Gillis was a founder
and director of Immunex Corporation.

An immunologist by training, Dr. Gillis has authored more than 300 peer-reviewed
publications in the areas of molecular and tumor immunology. He is credited as being a
pioneer in the field of cytokines and cytokine receptors, directing the development of
multiple marketed products including Leukine, (GM-CSF), Prokine (IL-2) and Enbrel (soluble
TNF receptor-Fc fusion protein) as well as the regulatory approval of Bexxar (radiolabeled
anti-CD20) and the novel vaccine adjuvant, MPL.

He received his B.A. from Williams College in 1975 and his Ph.D. from Dartmouth
College in 1978.

Dr. Gillis is a Non-Executive Director of Genesis Research and Development Corporation
Limited., a New Zealand and Australian Stock Exchange-listed biotechnology company. He was
a Non- Executive Director and then Executive Chairman and Acting President of Trubion
Pharmaceuticals Inc., until its sale in 2010.

Shire Chairman, Matt Emmens, comments:

“Steven’s pioneering and entrepreneurial approach paired with a deep technical and
scientific knowledge will complement the existing skills and outlook of the Shire Board. I
look forward to him joining in the autumn.”

Dr. Steven Gillis adds:

“Shire has a clear and ambitious patient-focused vision for the future and I look
forward to the opportunity to help them achieve it.”

There is no further information that is required to be disclosed under 9.6.13R of the
UK Listing Rules.

Notes to editors

Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients’ needs, we develop and provide healthcare
in the areas of:

        - Behavioral Health and Gastro Intestinal conditions
        - Rare Diseases
        - Regenerative Medicine

as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for patients,
physicians, policymakers, payors and our shareholders.


Statements included herein that are not historical facts are forward-looking
statements. Such forward-looking statements involve a number of risks and uncertainties
and are subject to change at any time. In the event such risks or uncertainties
materialize, the Company’s results could be materially adversely affected. The risks and
uncertainties include, but are not limited to, risks associated with: the inherent
uncertainty of research, development, approval, reimbursement, manufacturing and
commercialization of the Company’s Specialty Pharmaceuticals, Human Genetic Therapies and
Regenerative Medicine products, as well as the ability to secure new products for
commercialization and/or development; government regulation of the Company’s products; the
Company’s ability to manufacture its products in sufficient quantities to meet demand; the
impact of competitive therapies on the Company’s products; the Company’s ability to
register, maintain and enforce patents and other intellectual property rights relating to
its products; the Company’s ability to obtain and maintain government and other
third-party reimbursement for its products; and other risks and uncertainties detailed
from time to time in the Company’s filings with the Securities and Exchange Commission.

        For further information please contact:

        Investor Relations
        Eric Rojas

        Sarah Elton-Farr

        Jessica Mann (Corporate)

SOURCE Shire plc

Source: PR Newswire