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Assisted Reproduction: New Technology Identifies Previously Unknown Predictors of Embryo Viability

September 17, 2012

AARHUS, Denmark, September 18, 2012 /PRNewswire/ –

Which embryos have the best opportunity to develop into a viable pregnancy? A new
technology provides a surprising answer.

A major challenge in the field of IVF is selecting the single best embryo which is
likely to result in a live birth. Currently, embryologists must remove the embryo from a
standard incubator to perform 2 or 3 short evaluations of the developing embryo under the
microscope, at fixed time-points over 3-5 days, in order to assess embryo quality prior to
transferring an embryo to the patient.

(Photo:
http://photos.prnewswire.com/prnh/20120918/562489 )

The EmbryoScope(R) Time-lapse system generates a movie allowing embryologists to
monitor various characteristics of the embryo development over the entire incubation
period, while maintaining optimum incubation conditions in a state-of-the-art incubator.

According to breakthrough scientific results, embryos which exhibit irregular division
patterns have a much lower pregnancy potential. The results were made available online on
August 27 in the journal Fertility & Sterility, and confirms the benefits of implementing
the EmbryoScope(R) Time-lapse system from the Danish company Unisense FertiliTech A/S.

A clinical multi-center study from Equipo IVI, Spain, Maigaard clinic and Braedstrup
Hospital in Denmark, including a total of 5225 embryos, reports significantly reduced
implantation of embryos which have a second division cycle occurring in less than 5 hours
(considered direct cleavage), compared to the implantation probability of “normally”
developing embryos. The embryos with a short second division cycle will simply not have
enough time for DNA replication, which is a prerequisite for a normal cell division.

Nearly 14% of all examined embryos exhibited this division pattern and according to
the study will have a greatly reduced probability of resulting in a viable pregnancy. For
both patients and fertility clinics it is important to decrease transfer of embryos with
low very low implantation potential. With this new technology, clinics now have objective
criteria with which to identify the embryo with a higher chance of implanting allowing
more successful single embryo transfer cycles.

Marcos Meseguer, co-author of the paper and senior embryologist at Equipo IVI in
Valencia, states “The ability to identify abnormal development events in embryos is
certainly a key advantage of using time-lapse systems such as the Embryoscope(R) allowing
us to improve our patient treatment”.

The improvement potential of implementing time-lapse systems is increasing constantly
as scientists discover new information about early human embryo development and more than
180 IVF clinics are using the Embryoscope(R) technology worldwide.

About Unisense FertiliTech A/S:

Unisense FertiliTech A/S was founded in 2003 to develop technology to improve human
embryo assessment in assisted reproduction. Unisense FertiliTech has developed, and
manufactures the EmbryoScope(R)- a unique Time-lapse system facilitating improved IVF
treatment, flexible work routines and effective communication through comprehensive
documentation of embryo development and evolving improvements in selection. The System is
FDA 510(k) cleared and CE marked as a Class II medical device.

Our Mission is to help infertile couples achieve their dream of parenthood through
development of novel technology, quantification and digitized documentation. “The Vision
to Conceive”

        For further information please contact:
        CEO, Jens Gundersen
        Email: jkg@fertilitech.com

        COO, Soren Ankerstjerne
        Email: sa@fertilitech.com

+45(0)89449500

Unisense FertiliTech A/S

http://www.fertilitech.com [www.fertilitech.com ]


    Photo: 

http://photos.prnewswire.com/prnh/20120918/562489

SOURCE Unisense FertiliTech A/S


Source: PR Newswire