September 27, 2012
Possible Molecular Key Found In Regulating Ovarian Cancer Stem Cells
Researchers at Moffitt Cancer Center have discovered that the micro ribonucleic acid miR-214 plays a critical role in regulating ovarian cancer stem cell properties. This knowledge, said the researchers, could pave the way for a therapeutic target for ovarian cancer.
The study appears in a recent issue of the The Journal of Biological Chemistry.
“Evidence suggests that cancer stem cells are responsible for cancer initiation, progression, metastasis, chemoresistance and relapse,” Cheng said. “Data are emerging to support the role of both miRNAs and transcription factor p53 in cancer stem cell regulation.”
Their current study found that miR-214 regulates ovarian cancer stem cell properties by direct repression of p53, which led to induction of a stem cell transcription factor (Nanog). The researchers demonstrated that p53 mediated miR-214-induced Nanog in ovarian cancer stem cells and also induced chemoresistance.
“It is plausible that miR-214 has an important influence on stem cells through its capacity to modulate p53,” explained Cheng. “Our study demonstrates direct evidence that miR-214 plays a critical role in maintaining ovarian cancer stem cells.”
Given that knowledge, the researchers concluded that miR-214 is a potential therapeutic target for treating ovarian cancer.
The research was supported in part by the National Cancer Institute, part of the National Institutes of Health (grant numbers CA135328 and CA114343) and the U.S. Army (W81XWH-11-1-0223).
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