Last updated on April 20, 2014 at 17:20 EDT

Multimodal Treatment of Peritoneal Metastases Offers Hope for Many Patients With Colorectal Cancer

November 1, 2012

BERLIN, November 1, 2012 /PRNewswire/ –

8th World Congress on Peritoneal Surface Malignancies

At the 8th World Congress on Peritoneal Surface Malignancies held from October 30 to
November 2 in Berlin, Germany, a paradigm shift was emphasized that offers hope to
numerous cancer patients worldwide. So far patients with peritoneal metastases of solid
tumors in the abdominal region were considered not to be candidates for curative
treatment. These patients had an extremely poor prognosis and were treated solely with
systemic chemotherapy within the framework of “best supportive care.”

At the international congress definitive data was presented sharing that multimodal
treatment of peritoneal metastases of colorectal cancer can be a promising approach and is
associated with a five-year survival of up to 30-50%. Dr. Paul Sugarbaker (Washington, DC,
USA), surgeon and congress president, is considered a pioneer of this approach which uses
a combination of cytoreductive surgery (CRS), hyperthermic intraperitoneal chemotherapy
(HIPEC) and subsequent systemic chemotherapy. With HIPEC the chemotherapeutic agent is
distributed in the abdominal region at 42degree(s)C for about 60 to 90 minutes. “The
residual tumor tissue is exposed to a multiple of the normal concentration of the
cytotoxic agent that is administered during conventional chemotherapy,” explained
Sugarbaker. “This is why the method is successful. In selected patients it can double the
survival time – and should therefore be considered as a therapeutic option within an
individualized treatment approach”.

The aspect of individualized treatment is important, because the method is suitable
only for patients with isolated and limited peritoneal carcinomatosis without metastases
outside the abdomen. “However, this group constitutes up to 15% of all patients with
colorectal cancer after all,” pointed out Dr. Prof. Pompiliu Piso (Regensburg, Germany),
co-president of the congress. “In simple terms this means that in Germany, for example,
where there are 70,000 new cases of colon cancer each year, the prognosis of around 10,000
patients could be substantially improved by the use of this method.”

Further information



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SOURCE 8th World Congress on Peritoneal Surface Malignancies

Source: PR Newswire