November 11, 2012
Disappointing Results For Newborns In Experimental Malaria Vaccine Study
redOrbit Staff & Wire Reports — Your Universe Online
Less than one-third of newborns who received an experimental new vaccination against malaria were successfully protected from the potentially fatal disease, according to research presented Friday at a Vaccines for Africa conference in Cape Town, South Africa.
"That is a significant drop from a study last year done in slightly older children, which suggested the vaccine cut the malaria risk by about half -- though that is still far below the protection provided from most vaccines," Cheng said.
Last year's trial showed the vaccine protected against detectable forms of the disease in slightly over half (56 percent) of five to 17-month old children, Seattle Times Health Reporter Carol M. Ostrom wrote on Friday. It was also found to prevent severe cases of malaria in 47 percent in that age group.
In comparison, the latest research, which is part of a continuing evaluation of the vaccination being conducted by GSK and the PATH Malaria Vaccine Initiative, was found to be 31 percent effective against detectable malaria, and 37 percent against the more serious strain of the disease, Ostrom said. The results of the study were published in Friday's edition of the New England Journal of Medicine.
Likewise, malaria expert Genton Blaise, a member of a World Health Organization (WHO) advisory board who is also affiliated with the Swiss Tropical and Public Health Institute, said at its current efficacy level, that it is "probably not worth" implementing the vaccine "on a large scale" throughout Africa.
"This is an important scientific milestone and needs more study," Bill Gates, who is supporting the study through his Bill & Melinda Gates Foundation, added in a statement, according to Ostrom. "The efficacy came back lower than we had hoped, but developing a vaccine against a parasite is a very hard thing to do. The trial is continuing and we look forward to getting more data to determine whether and how to deploy this vaccine."
The study is currently scheduled to continue until 2014, according to Cheng.