Heptares Partners with Cubist to Research New Medicines Targeting GPCRs
WELWYN GARDEN CITY, England and BOSTON, January 7, 2013 /PRNewswire/ –
Heptares Therapeutics, the leading GPCR drug discovery and development company, today
announced they have signed an agreement with Cubist Pharmaceuticals, Inc. (Nasdaq: CBST)
to collaborate on the research and discovery of new medicines targeting G protein-coupled
receptors (GPCRs), which are membrane proteins involved in a broad range of biological
processes and diseases.
Under the terms of the agreement, Cubist will receive exclusive worldwide rights to
research, develop and commercialize products generated from the collaboration. The
collaborative research will focus on up to two GPCR drug targets to be selected by Cubist.
For the first target, Heptares will receive $5.5 million (USD) upfront and up to
approximately $4 million in research funding plus milestones and royalties. Cubist also
has the option to nominate a second GPCR target at a later point in the collaboration,
which Heptares has agreed to work on according to pre-determined financials. Further terms
of the agreement are not disclosed.
Steve Gilman, Cubist Executive Vice President, Research & Development and Chief
Scientific Officer said: “We are pleased to collaborate with Heptares, a recognized leader
in the GPCR field, to pursue potential new GPCR drug candidates. This partnership
underscores our commitment to develop a robust pipeline of novel products that address
high unmet medical needs in patients with acute diseases.”
“We are very excited to work with Cubist, one of the fastest growing biopharmaceutical
companies in the world and a commercial leader in the acute care therapeutics area,” said
Malcolm Weir, CEO of Heptares. “This agreement further demonstrates the strength of our
strategy to extend the reach of our unique platform across the GPCR universe through
partnerships with leading pharmaceutical and specialty companies, while advancing our own
proprietary pipeline into clinical development.”
About G protein-coupled receptors (GPCRs)
The GPCR superfamily is the largest and single most important family of drug targets
in the human body. It plays a central role in many biological processes and is linked to a
wide range of disease areas. GPCRs are expressed in every type of cell in the body where
their function is to transmit signals from outside the cell across the membrane to
signaling pathways within the cell, between cells and between organ systems. There are
over 375 GPCRs encoded in the human genome, of which 225 have known ligands and 150 are
orphan targets. GPCRs are the site of action of 25-30% of current drugs. Six of the top
ten and 60 of the top 200 best-selling drugs in the US in 2010 target GPCRs.
About Heptares Therapeutics
Heptares creates new medicines targeting clinically important, yet historically
challenging, GPCRs (G protein-coupled receptors), a superfamily of drug receptors linked
to a wide range of human diseases. Leveraging our advanced structure-based drug design
technology platform, we have built an exciting discovery and development pipeline of novel
drug candidates, which have the potential to transform the treatment of serious diseases,
including Alzheimer’s disease, Parkinson’s disease, schizophrenia, migraine and diabetes.
Our pharmaceutical partners include Shire, AstraZeneca, MedImmune, Takeda and Cubist, and
we are backed by MVM Life Science Partners, Clarus Ventures, Novartis Venture Fund and
Takeda Ventures. To learn more about Heptares, please visit http://www.heptares.com.
SOURCE Heptares Therapeutics
