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Last updated on April 17, 2014 at 15:32 EDT

Pharmaceutical Company Achieves Positive In-Vitro Testing Results Diabetes Drug

January 31, 2013

CORAL SPRINGS, Florida, January 31, 2013 /PRNewswire/ –

Crown Marketing Pharmaceuticals (OTC: CWNM [http://finance.yahoo.com/q?s=cwnm&ql=1 ])
announced today that it has achieved positive in-vitro testing results of the most widely
prescribed Diabetes drug commonly known as Metformin. Crown’s Controlled Drug Delivery
Device (CDDT) is less than half the size of the 500mg dosage tablet, and may reduce and
ameliorate many of the gastrointestinal side effects of Metformin. The most common adverse
effects of Metformin are gastrointestinal upset including diarrhea, cramps, nausea and
vomiting. Crown Marketing Pharmaceuticals (OTC: CWNM
[http://finance.yahoo.com/q?s=cwnm&ql=1 ]) believes it can significantly reduce or
eliminate these effects with its patented technology.

Patients also have issues about the taste and odor associated with the medication.
Common complaints are that it “smells fishy” and can leave a metallic taste in the mouth.
This is critical because it impacts patient compliance-if it tastes or smells bad,
patients oftentimes will not take the medication as directed. Crown’s CDDT can overcome
these issues due to its novel, diffusion based design and its impermable coating.
According to IMS figures, the total market sales for all forms of Metformin were $1.6
billion, with sales of Metformin extended-release formulation alone accounting for over
$460 million last year.

Metformin is an pharmaceutical oral diabetes medicine that helps control blood sugar
levels originally sold as Glucophage. Metformin is for people with type 2 diabetes.
Metformin is sometimes used in combination with insulin or other medications, but it is
not for treating type 1 diabetes. One of the more common long-term complications of
diabetes is diabetic renal disease (“renal” refers to the kidneys). Also known as diabetic
nephropathy, this condition is a result of direct vascular abnormalities that accompany
diabetes. Keryx Biopharmaceuticals Inc. (NASDAQ: KERX
[http://finance.yahoo.com/q?s=kerx&ql=1 ]) announced this week that its kidney disease
drug, Zerenex, is also receiving positive signs as it has performed better than a placebo
in late-stage clinical trials. The New York company said Monday that Zerenex showed a
“highly statistically significant” change in serum phosphorus levels compared with a
placebo in patients with advanced kidney failure who were on dialysis. Keryx
Biopharmaceuticals Inc. (NASDAQ: KERX [http://finance.yahoo.com/q?s=kerx&ql=1 ]) closed up
yesterday at $8.49 per share on large trading volume over 49.1Million shares traded.

The Global Pharmaceutical & Biotechnology sector continues to remain attractive, as
cost containment initiatives, restructuring/deconsolidation, share repurchase program,
M&A, emerging market growth potential and dividend policy continue to be encouraging. Over
the next few years, the growth of the industry would be shaped up by a battle between
fundamental growth drivers (Value added innovation) versus regulatory pressures to contain
costs. In Merger & Acquisition news, MAP Pharmaceuticals, Inc. (NASDAQ: MAPP
[http://finance.yahoo.com/q?s=mapp&ql=1 ]) is a biopharmaceutical company focused on
developing and commercializing new therapies to address undermet patient needs in
neurology. The Company is developing LEVADEX(R), an orally inhaled investigational drug
for the acute treatment of migraine. Allergan, Inc. (NYSE: AGN
[http://finance.yahoo.com/q?s=agn&ql=1 ]) inked a deal with MAP Pharmaceuticals, Inc.
(NASDAQ: MAPP [http://finance.yahoo.com/q?s=mapp&ql=1 ]) to acquire the latter. As per the
terms of the deal, Allergan will acquire all the shares of MAP Pharmaceuticals for $25.00
per share. The offer price represents premium of 60% over MAP Pharmaceuticals’ closing
price back on Jan 22, 2012.

Another leader in the sector, Amarin Corporation (NASDAQ: AMRN
[http://finance.yahoo.com/q?s=amrn&ql=1 ]) was originally a small British drug delivery
company, which evolved into a cardiovascular drug development company and is now among the
more promising biopharmaceutical companies in the US. Vascepa (icosapent ethyl) for
treatment of hypertriglyceridemia is Amarin’s first FDA approved product, whose market
introduction was announced by the company on January 24, 2013. Hypertriglyceridemia refers
to high blood level of triglycerides, a blood fat that contributes to cardiovascular
problems.

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Source: PR Newswire