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Zoledronic Acid Does Not Prevent Bone Metastases In High-Risk PCa Patients

March 19, 2013

The initial study results of the Zometa European Study (ZEUS) showed no difference in the incidence of bone metastases between the Zometa group and control arm, said Prof. Manfred Wirth during the closing and fourth plenary session of the 28th Annual EAU Congress which ends today.

“There is no difference in the incidence of bone metastases and there is no difference in survival,” said Wirth in his brief presentation on whether Zometa can prevent bone metastases in high risk, metastatic prostate cancer patients. The ZEUS study, supported by the EAU Research Foundation, looked into the efficacy and safety results after a median follow-up of 50 months. Zoledronic acid (Zometa®) is a third-generation nitrogen-containing Bisphosphonate, approved in Europe and the US for the treatment of bone metastases in a broad range of tumors.

Zoledronic acid was expected to show its potential in preventing hormone therapy induced bone loss. Patients were randomized between standard treatment plus Zometa® 4 mg infusions every three months for a total of 48 months. “There were regional variations in the numbers of patients who developed bone metastases,” added Wirth as he noted that locally treated patients developed less bone metastases.

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Source: European Association of Urology



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