Antibiotic Resistance 2013: The Antibiotics Development Pipeline and Strategies to Combat Antibiotic Resistance
DUBLIN, Ireland, April 2, 2013 /PRNewswire/ –
Research and Markets has announced the addition of the “Antibiotic Resistance 2013:
The Antibiotics Development Pipeline and Strategies to Combat Antibiotic Resistance”
[http://www.researchandmarkets.com/research/t5cn3l/antibiotic ] report to their offering.
This report gives a comprehensive overview of global antibiotic resistance, the
antibiotics pipeline and new strategies to target resistance mechanisms. It identifies 109
antibiotics in the development pipeline, approximately 70% of which are in early
development (Preclinical and Phase 1). In contrast, there are just 9 candidates at Phase
3, while there are 31 at Phase 2. These developments are being progressed by 66 companies,
of which nine (14%) are major international corporations and 57 (86%) are Small/Medium
Sized Enterprises (SMEs).
While antibiotics are effective for the majority of infections, increasing resistance
in some pathogens threatens to undermine the few remaining drugs that are still effective
against them. This is evident in the case of Klebsiella pneumoniae. Since 2005, there has
been a significant decrease of susceptibility to carbapenems in invasive Klebsiella
pneumoniae, causing concerns due to the lack of therapeutic options for treating these
Antibiotic resistance is a long-evolved trait in prokaryotes. The extensive
capabilities of the resistome, together with the ability of bacteria to establish new
mutant variants in response to man-made antibiotics, suggest that antibiotic resistance
will remain an ever-present threat. It is therefore not so much a question of whether a
pathogen will become resistant to an antibiotic, but when. However, the development of new
drugs and targeting mechanisms provide an opportunity to reset the clock on resistance
levels in particular pathogens.
In the last decade, the capacity to target pathogens has also been undermined by a
lack of innovation, which has seen a 60% fall in the numbers of new approvals and few
novel molecules. However, as this report has shown, this trend is changing. Today, there
are more than 100 candidate antibiotics in development, of which half are in the clinical
pipeline. While there are several promising candidates at Phase 3 which offer hope of new
approvals in the coming years, Phase 2 developments are now substantial, suggesting the
emergence of a new era in the types of antibiotics and the strategies that will be
available to target pathogens in the future.
Key Topics Covered:
Chapter 1 Introduction
1.1 Antibiotic Resistance 1.2 Resistance Mechanisms 1.3 The Resistome 1.4 Pathogenomics 1.5 Strategies and Targets 1.6 The Cost of Antibiotic Resistance 1.7 Global Surveillance 1.8 This Report Chapter 2 Antibiotic Resistance, Global Trends 2.1 Antibiotic Resistance 2.2 Europe 2.2.1 Carbapenem-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa (2005 to 2010) 2.2.2 Escherichia coli 2.2.3 Streptococcus pneumoniae 2.2.4 Staphylococcus aureus 2.2.5 Enterococcus faecalis 2.2.6 Klebsiella pneumoniae 2.2.7 Pseudomonas aeruginosa 2.3 Other Countries 2.4 China 2.5 USA 2.6 Kuwait 2.7 Discussion Chapter 3 Marketed Antibiotics 3.1 Marketed Antibiotics 3.2 Mechanisms 3.3 Companies 3.4 Sulphonamides 3.5 Beta Lactams (penicillins, cephalosporins, carbapenems, monobactams) 3.6 Aminoglycosides 3.7 Tetracyclines 3.8 Quinolones/Fluoroquinolones 3.9 Macrolides 3.10 Combinations 3.11 Folate antagonists 3.12 Mycobacterials 3.13 Glycopeptides 3.14 Others 3.15 Discussion Chapter 4 Pipeline Antibiotics 4.1 Pipeline Antibiotics 4.2 Companies 4.3 Phase 3 4.4 Phase 2 4.5 Phase 1 4.6 Preclinical 4.7 Discussion Chapter 5 Discussion 5.1 Background 5.2 Mechanisms 5.3 Multiple Activities 5.4 Marketed Antibiotics 5.5 Antibiotics Pipeline 5.6 Circumventing Resistance 5.7 Resistance Mutations 5.8 Virulence 5.9 Conclusions
For more information visit Antibiotic Resistance 2013: The Antibiotics Development
Pipeline and Strategies to Combat Antibiotic Resistance
Research and Markets Laura Wood, Senior Manager. email@example.com U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716
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