April 30, 2013
More Evidence Found Extolling The Health Benefits Of Green Tea
redOrbit Staff & Wire Reports - Your Universe Online
Researchers from the Keimyung University School of Medicine in South Korea have found new evidence supporting green tea´s role as a weight-loss aid, as well as an herbal remedy useful for glucose regulation in patients suffering from type 2 diabetes.
Writing in the most recent edition of the journal Naunyn-Schmedeberg´s Archives of Pharmacology, Jae-Hyung Park and his colleagues describe how they tested the impact of green tea extract on body weight and glucose intolerance in both diabetic mice and normal rodents being given a high-fat diet.
They focused on an active ingredient in green tea known as gallated catechins — a type of flavonoid which has been shown to inhibit intestinal glucose and lipid update, they explained in a statement.
Previous research has determined that the amount of gallated catechins required to reduce blood sugar levels can be obtained through a daily dose of green tea, but more is needed in order to decrease lipid uptake from the gut, and that amount could potentially be harmful to humans. Once in the bloodstream, gallated catechins can actually increase insulin resistance, another potentially adverse effect in obese and diabetic patients.
Park and his colleagues used a non-toxic resin known as polyethylene glycol in order to bind the gallated catechins in the gut to keep too high of a dose from being absorbed into the bloodstream. They then analyzed the effects of the mice eating only the green tea extract, as well as those eating the extract along with the polyethylene glycol, and compared them to the impact of two other medications typically prescribed to treat type 2 diabetes.
“Results showed that green tea extract in isolation did not give any improvements in body weight and glucose intolerance,” the journal publishers said in a statement. “However, when green tea extract was given with polyethylene glycol, there was a significant reduction in body weight gain, insulin resistance and glucose intolerance in both normal mice on a high fat diet and diabetic mice.”
“The polyethylene glycol had the effect of prolonging the amount of time the gallated catechins remained in the intestines, thereby limiting glucose absorption for a longer period,” they added. “Interestingly, the effects of the green tea extract in both the intestines and in the circulation were measurable at doses which could be achieved by drinking green tea on a daily basis.”
Furthermore, the impact of the green tea extract was found to be comparable to those when taking two of the medications currently recommended for diabetics who are non-insulin dependent.
The authors conclude that the combination of green tea extract and polyethylene glycol helped alleviate body weight gain and insulin resistance in diabetic and high-fat mice, thus improving glucose intolerance and proving that the combination of the two substances shows promise as “a preventative and therapeutic tool for obesity and obesity-related type 2 diabetes without too much concern about side effects.”