June 6, 2013
Herpes Virus Exploits Immune Response To Bolster Infection
Researchers at the University of California, San Diego School of Medicine and colleagues report that the herpes simplex virus type-1 (HSV-1), which affects an estimated 50 to 80 percent of all American adults, exploits an immune system receptor to boost its infectivity and ability to cause disease.
The findings are published in the June 6, 2013 issue of Nature Communications.
Led by principal investigator Richard L. Gallo, MD, PhD, professor of medicine and chief of UC San Diego's Division of Dermatology, the scientists found that HSV-1 launches an infection by binding to receptors on the surface of skin cells. Ordinarily, if a cell recognizes the virus as an invader, an immune response is immediately triggered, which includes a group of proteins called scavenger receptors that help identify and remove harmful viruses.
But sometimes the process goes awry. While studying HSV-1 and scavenger receptors in cultured human skin cells, Gallo and colleagues in the Atopic Dermatitis Research Network, funded by the National Institute of Allergy and Infectious Diseases, discovered that the virus strongly interacts with a particular receptor called a macrophage receptor with collagenous structure or MARCO, which it uses to gain entry into cells.
In tests comparing mice expressing normal levels of MARCO with mice genetically engineered to lack the receptor, the scientists found that MARCO enhanced the virus' ability to infect cells. Mice lacking the receptor suffered dramatically smaller skin lesions than normal mice with normal levels of MARCO. In a different experiment, the application of chemicals that prevented the virus from binding to MARCO resulted in much-smaller lesions on normal mice.
Gallo said the findings were surprising. "We would have predicted that MARCO would help resist infection," he said, noting it was the first evidence that a scavenger receptor, part of the body's defense system against viral invaders, might actually aid and abet HSV-1 infection.
The research suggests that development of new therapies preventing HSV-1-MARCO interaction may measurably reduce the degree and risk of serious HSV-1-related complications in atopic dermatitis patients and others. The scientists plan to follow up with testing in atopic dermatitis patients, and investigate whether other skin viruses also use the same infection pathway.
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