July 16, 2013
Extend HPV Jab To Young Gay Men
Anal cancer risk more than 15 times higher in gay than in straight men; targeted vaccination cost effective
The vaccination program against HPV infection began in 2008 in the UK, but only among girls, on the grounds that this would curb the spread of the infection to boys as well.
But, say the authors, from the Royal Liverpool University Hospital, Homerton University Hospital, and Chelsea and Westminster Hospital, gay men are more than 15 times as likely to develop genital cancer, particularly anal cancer, as a result of becoming infected with HPV, as are straight men.
While rates of anal cancers are higher among men who are also HIV positive - despite antiretroviral treatment - they are also higher among gay men who have not been infected with HIV, say the authors.
Data from Australia show that HPV vaccination of girls has had an impact on the prevalence of genital warts in straight men, but there has been no such change in prevalence among gay men, say the authors.
In February this year, Australia extended its school based HPV vaccination program to 12-13 year old boys, with a catch up program for 14-15 year olds.
Recent research has shown that the HPV jab is effective in men, including gay men. The vaccine covers HPV 16 and 18, the two strains of the virus which account for most of the cancers associated with the infection.
The vaccine is most effective in those who are not already infected with these strains of HPV, but the published evidence shows that only a minority of young gay men are, and that the strategy to vaccinate a group that includes those who have already been exposed to these strains is cost effective.
A recent analysis shows that the prevalence of anal HPV 16 and 18 among HIV negative men was 12.5% and just under 5%, respectively. Data from the UK's Health Protection Agency (now part of Public Health England) showed that fewer than one in 20 men under the age of 25 had been infected by any high risk HPV strain.
It's not clear how effective it is to screen gay men, particularly those who are HIV positive, for signs of pre-cancerous tissue changes, so this wouldn't be a viable alternative, say the authors, and would also preclude the introduction of universal screening.
Nevertheless, the argument for targeted vaccination is strong, they suggest, adding that sexual health clinics would be ideally placed to offer it, particularly as they already offer hepatitis B vaccination. In 2010, 17,000 gay men between the ages of 16 and 26 visited these clinics in England.
And HPV vaccination would help prioritize initiatives to improve access to services for this group, who remain vulnerable to HIV infection, the authors argue.
They admit that the biggest challenge will be to identify and vaccinate young gay men before they acquire HPV infection, but they point to recent data showing that vaccination of sexually active gay men is both clinically and cost effective.
"In the light of this evidence, and in the absence of universal vaccination of boys, the argument for introducing targeted HPV vaccination for [men who have sex with men] up to age 26 years is strong," they conclude.
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