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Last updated on April 19, 2014 at 5:20 EDT

Alliqua Initiates Proof-of-Principle Study of Transdermal Lidocaine Hydrogel Patch for Pain Relief

July 23, 2013

LANGHORNE, Pennsylvania, July 23, 2013 /PRNewswire/ –

Alliqua, Inc. (OTCQB: ALQA) (“Alliqua” or the “Company”) today announced the
initiation of a preclinical proof-of-principle study of an experimental hydrogel patch
containing lidocaine. Safety and tolerability of Alliqua’s lidocaine hydrogel patches will
be explored in an animal model. Further, the pharmacokinetic profile will be analyzed to
determine the amount of systemic absorption and local lidocaine concentration in the skin
immediately beneath the patch.

“The ease of use, stability and compatibility with active ingredients make our
hydrogels well suited for the transdermal delivery of a variety of compounds, including
pain medications like lidocaine,” commented James Sapirstein, chief executive officer of
Alliqua Biomedical. “Our lidocaine patch development program is just the first in our
effort to build a portfolio of products that leverage our hydrogel platform. We believe
success in this proof-of-principle study for our lidocaine patch would increase the
likelihood of success with other compounds and greatly enhances our efforts in this area.
Beyond lidocaine, the Alliqua Biomedical division plans to explore transdermal delivery of
dermatological, oncology, antibiotic and neurology products.”

The Company plans to develop lidocaine hydrogel patches for the treatment of localized
acute pain, including post-operative pain, back pain, as well as pain associated with
sports injuries and arthritis. Alliqua expects results from this preclinical
proof-of-principle study later in the third quarter.

“Lidocaine is an important therapeutic agent with a strong potential market
opportunity,” Mr. Sapirstein added. “Following successful completion of this
proof-of-principle study, Alliqua intends to develop a clinical and development path
forward based on discussions with the U.S. Food and Drug Administration as well as
scientific advisers and potential partners.”

About Alliqua, Inc.

Alliqua is a biopharmaceutical company focused on the development, manufacturing, and
distribution of proprietary transdermal wound care and drug delivery technologies.
Alliqua’s leading technology platform produces hydrogels, a 3-dimensional cross-linked
network of water soluble polymers capable of numerous chemical configurations.

Alliqua currently markets its new line of 510(k) FDA-approved hydrogel products for
wound care under the SilverSeal(R) brand. Alliqua’s electron beam production process,
located at its 16,000 square foot GMP manufacturing facility in Langhorne PA, allows
Alliqua to aggressively develop and custom manufacture a wide variety of hydrogels.
Alliqua’s hydrogels can be customized for various transdermal applications to address
market opportunities in the treatment of wounds as well as the delivery of numerous drugs
or other agents for pharmaceutical and cosmetic industries. Additionally, Alliqua’s drug
delivery platform, in combination with certain active pharmaceutical ingredients, can
provide pharmaceutical companies with a transdermal technology to enhance patient
compliance and potentially extend the patent life of valuable drug franchises.

For additional information, please visit http://www.alliqua.com. To receive future
press releases via email, please visit: http://ir.stockpr.com/alliqua/email-alerts.

Any statements contained in this press release regarding our ongoing research and
development and the results attained by us to-date have not been evaluated by the U.S.
Food and Drug Administration.

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entry of new competitors and products, adverse federal, state and local government
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products, technical problems with our research and products, price increases for supplies
and components, inability to carry out research, development and commercialization plans,
loss or retirement of key executives and research scientists and other specific risks. We
currently have no commercial products intended to diagnose, treat, prevent or cure any
disease. The statements contained in this press release regarding our ongoing research and
development and the results attained by us to-date have not been evaluated by the U.S.
Food and Drug Administration. There can be no assurance that further research and
development, and/or whether clinical trial results, if any, will validate and support the
results of our preliminary research and studies. Further, there can be no assurance that
the necessary regulatory approvals will be obtained or that we will be able to develop new
products on the basis of our technologies. In addition, other factors that could cause
actual results to differ materially are discussed in our Annual Report on Form 10-K/A
filed with the SEC on May 16, 2013 and our most recent Form 10-Q filings with the SEC.
Investors and security holders are urged to read these documents free of charge on the
SEC’s web site at http://www.sec.gov. We undertake no obligation to publicly update or
revise our forward- looking statements as a result of new information, future events or
otherwise.

        Contacts for Alliqua, Inc.
        Steven Berger
        Chief Financial Officer
        +1-646-218-1450
        info@alliqua.com

SOURCE Alliqua, Inc.


Source: PR Newswire