Last updated on April 16, 2014 at 13:48 EDT

Creabilis Appoints Professor Gil Yosipovitch and Professor Praveen Anand to its Scientific Advisory Board

July 29, 2013

CANTERBURY, England, July 29, 2013 /PRNewswire/ –

Creabilis SA, a late stage European dermatology company with a focus on chronic
pruritus (itch), today announces that it has appointed Professor Gil Yosipovitch and
Professor Praveen Anand to its Scientific Advisory Board.

Gil Yosipovitch is the newly announced Chair of the Department of Dermatology and
Director of the Temple Itch Center at Temple University School of Medicine, and is one of
the world’s renowned experts in pruritus. He was formerly Professor of Dermatology,
Neurobiology and Anatomy and Regenerative Medicine at the Wake Forest University School of

Professor Yosipovitch`s major clinical interest is pruritus, and his research focuses
on the neurophysiology of itch. He chaired the first International Workshop for the Study
of Itch in Singapore in 2001 and is the founder and past president of the International
Forum for the Study of Itch (IFSI), which is a multidisciplinary international association
of clinicians and researchers dedicated to improving the understanding of itch.

Professor Yosipovitch serves on the Editorial board of seven dermatology journals
including the Journal of the American Academy of Dermatology (JAAD), Experimental
Dermatology and Acta Dermatol Venereol. He has been awarded several prestigious awards
including the Rothschild Foundation award, and the Leo Foundation award in 2012 for
research on itch. He has an MD from the Sackler Faculty of Medicine at Tel- Aviv
University, Israel.

Praveen Anand is Professor of Clinical Neurology and Head of the Centre for Clinical
Translation at Hammersmith Hospital, Imperial College London, UK. Professor Anand is an
internationally recognised scientist and clinical researcher in chronic pain. His research
focuses on the pathophysiological and molecular mechanisms in human sensory neuropathies
and chronic pain syndromes.

Professor Anand has been involved in several collaborations with pharmaceutical
companies that bridge the gap between pre-clinical developments and their successful
clinical applications. This translational approach has guided the recent success of three
novel pain drugs from the laboratory to Phase 2 trials for chronic neuropathic pain.

Professor Anand received his medical education at the Universities of Oxford and
Cambridge. His post-graduate training was at the Hammersmith Hospital and the National
Hospital for Neurology and Neurosurgery, Queen Square, London.

On the Advisory Board, Professors Anand and Yosipovitch join other leaders in their
fields including Professor Jonathan Barker (Head of Department at St John’s Institute of
Dermatology, King’s College London), Professor Carlo Pincelli (Chief of the Laboratory of
Cutaneous Biology, Institute of Dermatology, University of Modena and Reggio Emilia,
Italy) and Professor Lars French (Professor and Chair of the Department of Dermatology,
University Hospital Zurich, Switzerland), and Regulatory and Pharmacology industry experts
Dr Lee Simon and Dr Alan Bye.

Professor Gil Yosipovitch, commenting on his appointment, said: “I am very honoured to
join the Creabilis Scientific Board. Chronic pruritus is a debilitating symptom of many
diseases and yet there is an unmet need to develop specific topicals that address itch.
Creabilis has delivered clinically meaningful Phase 2b data in pruritus with CT327 which
suggests the product has the potential to make a real difference to the lives of patients
suffering from the condition. I look forward to working with the experienced Creabilis
team to help achieve this goal.”

Professor Praveen Anand, commenting on his appointment, said: “I’m delighted to join
the Creabilis Scientific Board. Neuropathic pain is an area of significant unmet need.
CT340, with its novel dual analgesic and anti-inflammatory mechanism of action and strong
pre-clinical data has the potential to meet this need. Creabilis is at an exciting stage
of its development, with CT327 in late stage development for chronic pruritus and CT340
IND-ready in neuropathic pain. Given the mechanistic similarities between pruritus and
pain, I am excited to begin working with Creabilis to realise the potential of both CT340
and CT327.”

Professor Jonathan Barker, Chair of the Scientific Advisory Board said: “Professors
Anand and Yosipovitch bring further world-class expertise to an outstanding Advisory Board
which will allow the Board to provide key scientific and clinical advice to Creabilis. It
is a reflection of the quality of Creabilis’ recent clinical data with CT327 in chronic
pruritus, and pre-clinical data with CT340 in neuropathic pain, that we have been able to
attract individuals of Gil and Praveen’s calibre to our Scientific Advisory Board.”

About Creabilis SA

Creabilis is a late clinical stage European biotechnology company with a primary focus
in chronic pruritus (itch), a debilitating symptom of many dermatological diseases with a
negative impact on quality of life. Chronic pruritus is an area of significant unmet need,
with no medicine currently approved for its treatment.

Creabilis has delivered positive Phase 2b results for CT327 in the treatment of
pruritus in psoriasis patients. CT327 is a novel, first-in-class, topically delivered TrkA
kinase inhibitor. CT327 was developed using Creabilis’ proprietary Low Systemic Exposure
(LSE) ‘topical-by-design’ technology. LSE creates molecules optimized for topical
applications. Planning for Phase 3 with CT327 is underway, with a clear route to market
and an estimated >$800m in peak annual sales.

Creabilis’ pipeline also includes CT340, a potent narrow spectrum kinase inhibitor in
development for the topical treatment of neuropathic pain, an area of significant unmet
medical need. Like CT327, CT340 was developed using the Company’s Low Systemic Exposure
(LSE) technology. CT340 is IND-ready and first-in-human studies will commence in 2013.

Creabilis is backed by highly respected life science investors Sofinnova Partners,
Neomed and AbbVie Biotech Ventures Inc., and is led by an experienced Management team,
with over 100 years of combined R&D experience in pharma and biotech, and over 20 drug
approvals. Creabilis has corporate and R&D functions in the UK and Italy.

        For further information please contact:

        Eliot Forster
        Creabilis Ltd
        6 Denne Hill Business Centre
        Canterbury CT4 6HD

        Citigate Dewe Rogerson
        Chris Gardner or Nina Enegren
        Tel: +44(0)20-7282-1050
        E-mail: nina.enegren@citigatedr.co.uk

SOURCE Creabilis SA

Source: PR Newswire