July 29, 2013
Impaired Visual Signals Might Contribute To Schizophrenia Symptoms
By observing the eye movements of schizophrenia patients while playing a simple video game, a University of British Columbia researcher has discovered a potential explanation for some of their symptoms, including difficulty with everyday tasks.
The research, published in a recent issue of the Journal of Neuroscience, shows that, compared to healthy controls, schizophrenia patients had a harder time tracking a moving dot on the computer monitor with their eyes and predicting its trajectory. But the impairment of their eye movements was not severe enough to explain the difference in their predictive performance, suggesting a breakdown in their ability to interpret what they saw.
"An impaired ability to generate or interpret efference copies means the brain cannot correct an incomplete perception," says Spering, who conducted the dot-tracking experiments as a postdoctoral fellow at New York University, and is now conducting similar studies at UBC. The brain might fill in the blanks by extrapolating from prior experience, contributing to psychotic symptoms, such as hallucinations.
My vision would be a mobile device that patients could use to practice that skill, so they could more easily do common tasks that involve motion perception, such as walking along a crowded sidewalk.
"But just as a person might, through practice, improve their ability to predict the trajectory of a moving dot, a person might be able to improve their ability to generate or use that efference copy," Spering says. "My vision would be a mobile device that patients could use to practice that skill, so they could more easily do common tasks that involve motion perception, such as walking along a crowded sidewalk."
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